ANTI-AGEING 47 a
9000% 8000% 7000% 6000% 5000% 4000% 3000% 2000% 1000% 0%
n Natpure Xtra Eternity n Cocoa Benchmark
KRT 1
KRT 10 KRT2 KRT6A SPRR1A SPRR1B FLG CASP14 CALML5 TGM1 Genes involved in the formation of the
Genes of keratin components
b Normal c Dry Stress
150 100 50 0
Dry Stress + Eternity x p=0.0420
epidermis outer layer (Stratum Coruem) d
Evaluation of Aquaporine-3 staining ns p=0.1167
ns p=0.0547 x p=0.0247 +27.9% -25.0%
20 16 12 8 4 0
* ** *
Minutes 30
days Time
28
days 84
Figure 4: (A) Natpure Xtra Eternity and a benchmark cocoa extract differentially modulate the expression of genes implicated in the cornification of the epidermis. (B - C) Immunofluorescence staining of Aquaporin-3 on a reconstituted human epidermis under normal, dry stress and dry stress + Natpure Xtra Eternity conditions. Aquaporin-3 is stained in red. (D) Natpure Xtra Eternity moisturises the skin in vivo.
potential for the maintenance of skin health. Nutrients 2014; MDPI AG.
5 Kim J, Lee KW, Lee H J. Cocoa (Theobroma cacao) Seeds and Phytochemicals in Human Health. In: Nuts and Seeds in Health and Disease Prevention 2011; 351–360.
6 Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and extrinsic factors in skin ageing: A review. Int. J. Cosmet. Sci. 2008; 30: 87–95.
7 Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M. Role of matrix metalloproteinases in Photoaging and photocarcinogenesis. International Journal of Molecular Sciences 2016; MDPI AG.
8 Ovaere P, Lippens S, Vandenabeele P, Declercq W. The emerging roles of serine protease cascades in the epidermis. Trends in Biochemical Sciences 2009; 34(9): 453-463
9 Candi E, Knight RA, Panatta E, Smirnov A, Melino G. Cornification of the Skin: A Non- apoptotic Cell Death Mechanism. In eLS (pp. 1–10). John Wiley & Sons, Ltd, 2016.
10 Hara-Chikuma M, Verkman AS. Roles of aquaporin-3 in the epidermis. Journal of Investigative Dermatology 2008; 128(9): 2145- 2151
August 2020 B
Formulation 1: SCT 4178b Cocoa Light Lotion Phase
Ingredients A Water
Butylene Glycol Solubilisant LRI1
Natpure Xtra Eternity1 Covacryl RH1
Montanov 2022 Dermol 993
Cetiol OE4 C Sepiplus 4002 Simugel NS2 D
Euxyl PE90105 Citric Acid 10%6
White Tea Fragrance Water Butylene Glycol
PPG-26-Buteth-26 (and) PEG-40 1.50 Hydrogenated Castor Oil (and) Water
Theobroma Cacao (Cocoa) Extract Sodium Polyacrylate
Arachidyl Alcohol (and) Behenyl Alcohol 2.50 (and) Arachidyl Glucoside
Isononyl Isononanoate Dicaprylyl Ether
Polyacrylate-13 & Polyisobutene & Polysorbate 20
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer (and) Squalane (and) Polysorbate 60
Phenoxyethanol (and) Ethylhexylglycerin Citric Acid pH Fragrance
Suppliers: 1 Sensient Cosmetic Technologies 2 Seppic 3 Alzo 4 BASF 5 Schülke 6 Sensient Fragrance
PERSONAL CARE GLOBAL
INCI
% w/w q.s.
5.00 1.50 2.00
0.50 2.50 7.00
3.00 0.75
0.75
0.70 5.50 0.20
Gene expression (% of basallevel)
IF AQP3 (%)
Moisturizing variations (%)
Normal
Normal_Active 100 µg/ml Dry Stress
Dry Stress+ Active 100 µg/ml Dry Stress+ Active 50 µg/ml
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