SKIN CARE 27 n Placebo n 3% FBC Complex n 3% Benchmark moisturizing active
90 80 70 60 50 40 30 20 10 0
t=2 h t=21 d
Figure 6: Relative improvement of skin moisture after 1 application on normal skin (%), measured with Novameter®
DPM 9003 in a moisture accumulation test 2 hours after application and after 21 days of twice daily application.
assessed using a Primos 5.7 high res (GFMesstechnik). With this optical technology, the precise 3-dimensional topography of skin can reliably be determined. A consumer study was performed as well and the combined results of all in vivo studies were clear.
Skin capacitance The moisturising effect of FBComplex at 3% in a cosmetic formulation was compared to a control formulation not containing FBComplex (placebo) in two different studies. First of all, using a Corneometer MPA 5 CPU, the eight-hour moisturising effect of FBComplex was measured on normal skin after a single application on 20 volunteers. The results are presented in Figure 3. After 2 hours the formulation containing FBComplex performed 78% better than the corresponding placebo formulation. After 4 hours this difference was 65%, and after 8 hours 173%. In a second study, the direct moisturising activity of FBComplex was assessed on dry skin on 22 volunteers with the Corneometer
10 8 6 4 2 0 t=1h t=2h
Figure 8: Relative increase in skin smoothness after 1 application on dry skin (%). Measured with Primos®
5.7 high res one and two hours after application. August 2020
Figure 7: Relative decrease in visual skin dryness as determined with the Diagnoskin System®
(%) after 21 days of twice daily application.
CM825™. After 2 hours measurements were performed, and the results are presented in Figure 4. Although the relative difference between the formulation containing FBComplex and its corresponding placebo were already remarkable in the study performed on normal skin, the results obtained with the study on dry skin further confirm the potency of FBComplex in directly moisturising skin.
Capacitance imaging To further underline the direct moisturising effects of FBComplex, the study including 22 volunteers with dry skin was continued with assessing the skin moisture level using the MoistureMap technology. A remarkable difference between the formulation containing FBComplex and its corresponding placebo could be detected in this way as well. See Figure 5 for the results obtained. The formulation containing FBComplex outperformed the placebo formulation by more than three times.
n Placebo n 3% FBC Complex
Moisture accumulation test Both short-term and long-term moisturising efficacy was determined with a Novameter. This study was also performed on 22 volunteers with dry skin. Here the direct moisturising effects were determined 2 hours after a single application. The long- term moisturising effects were determined after 21 days of twice daily application, with the last application of the test formulations taking place 12 to 16 hours before the measurements. Apart from placebo and the corresponding formulation with 3% FBComplex, a third formulation was included in this study. The base formulation was identical to the base formulations of placebo and that with FBComplex, but contained 3% of a benchmark moisturising active ingredient which can be assumed to be one of the most successful high-end moisturisers in the cosmetic industry. The results are shown in Figure 6. Untreated control is set at 0%. The direct moisturising activity of FBComplex was already convincingly proven using the corneometer and MoistureMap. It was further affirmed by performing the moisture accumulation test. Comparable to the results obtained with MoistureMap, the formulation containing FBComplex clearly outperformed the corresponding placebo formulation by more than five times. FBComplex’s ability to directly hydrate the skin is particularly strongly revealed in this study when a comparison is made with the benchmark moisturiser: FBComplex’s moisturising effect two hours after the application was almost twice (98%) as strong as that of the benchmark ingredient. The long-term moisturising properties
were proven with MAT as well. Even 12 to 16 hours after the last application of the test formulations, after having applied these formulation two times per day for a total of 21 days, the formulation containing FBComplex convincingly showed a long-
PERSONAL CARE GLOBAL
14 12 10 8 6 4 2 0
n Placebo n 3% FBC Complex n 3% Benchmark moisturizing active
Increase in skin hydration % Increase in skin smoothness %
Decrease in visual skin dryness %
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