18 SKIN CARE *SA-ß-Gal Senescence-associated ß-galactosidase no LPS Control -UVA/ - Ferment + LPS +33%
LPS + 2%
Cranberry ferment
0 20 40 60 Cell viability (%) Figure 2: Cell viability.
bacteria and self preservation while also being biome friendly. Just as LAB- fermentation, Aplha Hydroxy Acids (AHAs) also have beneficial properties, both for the outer skin layer (epidermis) and the deeper layer (dermis). AHAs are said to have an exfoliating effect on the skin and serve as a natural moisturiser while supporting the firmness of the skin. ADEKA offers five different types of
prebiotic bio-fermented fruit extracts. Kiwi (Actinidia Chinensis (Kiwi) Fruit Water, Lactobacillus Ferment), Cranberry (Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment), Green Tea/ Ginger (Camellia Sinensis Leaf Extract, Zingiber officinale (Ginger), Water, Lactobacillus Ferment), Cocos (Cocos Nucifera (Coconut) Fruit Juice, Lactobacillus Ferment) and Apple/ Matcha (Pyrus malus (Apple), Fruit Water, Camellia Sinensis Leaf, Lactobacillus Ferment)(Fig 1).
Actinidia Chinensis (Kiwi) Fruit Water, Lactobacillus Ferment Actinidia Chinensis (Kiwi) Fruit Water, Lactobacillus Ferment is suitable for skin and hair care products as well as for sun care and anti-ageing cosmetics. It can
80 100 + UVA
Green Tea/ Ginger Ferment (2%)
-40% + UVA (10 J/cm2 )
0
20
40
60 SA-ß-Gal* positive cells (%) Figure 3: Levels of Beta Galactosidase.
reduce the appearance of wrinkles and fine lines, has skin firming properties, contains vitamin C + E and polyphenols and is antioxidant. A study has shown that LAB-
fermentation leads to a 22% increase in anti-radical scavenging activity of Kiwi fruit ferment compared to a non-fermented control. Hence, Actinidia Chinensis (Kiwi) Fruit Water, Lactobacillus Ferment exhibited higher antioxidant activity to scavenge free radicals.
Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment is suitable for skin, eye and hair care. It contains vitamin A + C and is expected to deeply moisturise, nourish, sooth and tighten the skin. Furthermore, studies have shown that Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment decreases LPS-mediated cell death. Primary fibroblast were treated with Lipopolysaccharide (LPS), a bacteria-derived strong inducer of inflammatory processes, leading to cell death. Only 60% of a cell population survived in presence of LPS without
Collagen Ferment
+50% Collagen I
+2% Cocos ferment
Collagen III +2% Cocos ferment
+155% Activated 5-
Lipoxygenase +
1 % Apple/ Matcha ferment 57% Activated 5-
Lipoxygenase +
NDGA*
(synthetic inhibitor)
93%
Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment. In the presence of LPS in combination with 2% of Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment the percentage of viable cells can be increased by up to 33% compared to LPS only treated cells. Therefore, Vaccinium Macrocarpon (Cranberry) Fruit Juice, Lactobacillus Ferment shows cyto protective activity against bacterial induced cell death (Fig 2).
Camellia Sinensis Leaf Extract, Zingiber officinale (Ginger), Water, Lactobacillus Ferment Camellia Sinensis Leaf Extract, Zingiber officinale (Ginger), Water, Lactobacillus Ferment is suitable for hair and skin care cosmetics. It is anti-inflammatory, antimicrobial, antioxidant and contains catechine. A study has furthermore shown, that cellular ageing upon UVA irradiation can be inhibited through phenolic compounds of Green Tea and bioactive compounds, like shogaols, from Ginger. Human dermal fibroblast without exposure of UVA showed only 10% of senescent cells of the whole population. After exposure of UVA with 10 J/ cm² without Camellia
*NDGA - Nordihydroguaiaretic acid
80
100
0
100
150
200 Figure 4: Relative Collagen I and III expression. PERSONAL CARE GLOBAL
250 Relative Collagen I and III expression (%) Figure 5: Lipoxygenase inhibition. August 2020
300
0
20
40
60 Lipoxygenase inhibiton (%)
80
100
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