48 MARINE INGREDIENTS UNTREATED UV IRRADIATION UV IRRADIATION + B-LIGHTYLTM 3%
Figure 4: Decrease of lipofuscin accumulation (ex vivo). Student’s t-test: ***p<0.001, *p<0.05
increase of the lipofuscin content can be observed (+69%). The macro-alga extract significantly decreases UV-induced lipofuscin accumulation, down to -39%.
How to target pigmented spots for all skin ethnicities? To evaluate the consumers’ benefits of the macro-alga extract against dark spots and pigmentation disorders, three clinical tests were conducted in double blind versus placebo, on nearly 100 volunteers from various ethnic skin types (African, Asian and Caucasian), demonstrating the universal efficacy of the ingredient. They have highlighted that the macro-alga extract significantly decreases the melanin content in dark spots, while also reducing their number (up to 4 times better than placebo). Thanks to its unique and innovative mode of action, combined to a proven clinical efficacy, the macro-alga extract is the perfect natural ingredient to fight against dark spots and hyperpigmentation, no matter their cause. The first study was carried out on 20
female volunteers with Caucasian skin type, from 50 to 75 years old, selected for their pigmented ageing spots on the hands. Volunteers applied a formula containing the macro-alga extract at 3% or a placebo (same formula without the active) on each of their hands, twice a day for 28 days. The melanin content in the dark spots of the volunteers was evaluated thanks to a Mexameter® at D0 and after 28 days of treatment. It results that the macro-alga extract induces a significant reduction of the melanin content in the dark spots of the volunteers, down to -12.6% versus D0 after 28 days. This is a significant decrease by -103% versus placebo (more than a factor 2). The second study was carried out
on 36 female volunteers with Asian skin type, from 45 to 65 years old, selected for their pigmented ageing spots on the face. Volunteers applied a formula containing the macro-alga extract at 3% or a placebo (same formula without the active) on hemiface, twice a day for 56 days. The number of visible spots on the face of the volunteers was evaluated using VISIA® CR2.0 at D0 and after 28 and 56
Volunteer 27-53 years old
days of treatment. It appears that the macro- alga extract induces a significant reduction of the number of visible spots on the faces of the volunteers, down to -156% and -292% versus placebo, respectively after 28 and 56 days. The third study was carried out on 43
female volunteers with African skin type, from 19 to 54 years old, selected for their hyperpigmentation spots on the face. Volunteers were divided into 2 groups, applying either a formula containing the macro-alga extract at 3% or a placebo (same formula without the active) on their full face, twice a day for 56 days. As African skin is very rich in melanin (potent UV protector), it usually shows fewer age spots due to UV exposure or senescence than other skin types. However, it is prone to hyperpigmentation disorders which can be related, for instance, to an over production of melanin during wound healing. Therefore, for this clinical test, volunteers were selected for their hyperpigmentation disorders on the faces, no matter their age (19 to 54 years old). The melanin content in the dark spots of the volunteers was then evaluated thanks to a Mexameter® at D0 and after 28 and 56 days of treatment. The macro-alga extract induces a significant reduction of the melanin content in the hyperpigmented spots of the volunteers, down to -91% and -327% versus placebo, respectively after 28 and 56 days. To inspire the beauty industry and
concretely show the macro-alga extract efficacy, the active ingredient was formulated by our experts in an inspirational skin complexion boosting essence called S3D® Oceanist. This luxurious formula combines the macro-alga extract together with radiance booster, Eutectys™ Sea Fennel, and moisturising water rich in sea minerals sourced from Brittany (Eau de Source Marine). Its “fat water” texture (a new 2020 skin care trend) gives the product a consistency between the essence and the serum, and its delicate smell makes S3D® Oceanist the perfect beauty product to smooth the skin, erase dark spots and even out complexion.
D0 D56
Figure 5: Reduction of pigmented spots on faces (Asian skin). Illustrative pictures (VISIA®), B-Lightyl™ at 3%
PERSONAL CARE April 2021
References 1. Yoon JE et al. Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo. Theranostics. 2018 Sep 9;8(17):4620-4632
www.personalcaremagazine.com
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