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SILICONES TRISILOXANYL CANNABIDIOL H OH hydrolysis H H2 O o Si


o Si


o Si


Si o Si o Si o Si o Si o Si Silicone gel


Si o Si o Si o Si o Si o Si Silicone gel


Figure 4: Release mechanism of trisiloxanyl-cannabidiol interacting with silicone gel. Upon introduction of water, the Si-O-C bond is hydrolyzed, resulting in the formation of fully active CBD.


of Cannabidiol Users. Cannabis Cannabinoid Res. [Internet] 2018 Jul [cited 2021 Feb 12] 1;3(1):152-161.


2. Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. [Internet] 2012; [cited 2021, Feb 12] 209(6):1121- 1134.


oster Keunen 2ChAd 21.qxp_Layout 1 15/02/2021 21:32 Page 1


3. Scheau C, Badarau IA, Mihai L-G, Scheau A-E, Costache DO, Constantin C, Calina D, Caruntu C, Costache RS, Caruntu A. Cannabinoids in the Pathophysiology of Skin Inflammation.Molecules. [Internet] 2020; [cited 2021 Feb 12] 25(3):652.


4. Palmieri B, Laurino C, Vadalà M. A therapeutic H HO CBD H OH


43


Figure 5: Left: PDMS gel cured with hemp seed oil, Right: PDMS gel cured with trisiloxanyl-cannabidiol.


effect of CBD-enriched ointment in inflammatory skin diseases and cutaneous scars. Clin Ter. [Internet] 2019; [cited 2021 Feb 12] 170(2): e93-e99.


5. Abu-Sawwa R, Stehling C. Epidiolex (Cannabidiol) Primer: Frequently Asked Questions for Patients and Caregivers. J Pediatr Pharmacol Ther. [Internet] 2020; [cited 2021 Feb 12];25(1):75-77.


6. Medical News Today. Everything you need to know about CBD. [Internet] March 2020. [cited 2021 Feb 12]


7. Oláh A, Tóth BI, Borbíró I, et al. Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. J Clin


Invest. [Internet] 2014; [cited 2021 Feb 12] 124(9):3713-3724.


8. Grand View Research. Industry Analysis. [Internet] Cannabidiol CBD Market Dec 2019. [cited 2021 Feb 12]


9. Forbes. CBD Market. [Internet] May 2019 [cited 2021 Feb 12] Available from: https:// www.forbes.com/sites/irisdorbian /2019/05/20/cbd-market-could- reach-20-billion-by-2024-says-new- study/?sh=36fd737649d0


10. Arkles B, Goff J, Min T, Pan Y. Roberman T. Silicon-based Cannabidiol Derivatives and Compositions Thereof, US Patent 10,933,008, 2021


www.personalcaremagazine.com


April 2021 PERSONAL CARE


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