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40 SILICONES


A CBD hybrid with enhanced flexibility


Tanya Roberman, Kerry DeMella, Richard Liberatore, Barry Arkles, Jonathan Goff – Gelest, US


In 2018, hemp-derived CBD, one of many Cannabinoids present in Cannabis sativa plants, was federally legalised under the US Farm Bill. Although hemp belongs to the same family of plants as marijuana, it contains less than 0.3% THC (delta-9-tetrahydrocannabinol). Unlike THC, hemp-derived CBD lacks any psychoactive effects and does not qualify as a controlled substance. Since its legalisation, CBD has gained massive interest across the regulated medical and pharmaceutical industries, and numerous studies have shown potential benefits of CBD in treating anxiety, depression, sleep disorders, and other related conditions.1 Several studies have also shown that CBD usage can aid in suppressing inflammatory and neuropathic pain,2


and several recent


publications tested Cannabinoids’ potential for treating inflammatory skin conditions3 cutaneous scars.4


In addition and The FDA has recognised the


benefits of CBD in its decision to approve the 2019 drug Epidolex®, the first CBD-based oral drug for patients with epilepsy.5


to scientific industries, there has also been significant interest in CBD in the naturopathic and personal care and wellness markets. Although more investigation is needed, Medical News Today cited a study published in the Journal of Clinical Investigation which reported promising results from the use of CBD in acne treatment,6


sebaceous glands.7


claiming reduced inflammation in Topical application of CBD


may also reduce inflammation in psoriasis and other skin diseases. According to Grand View Research, the global CBD market was estimated at 4.6 billion USD in 2018,8


and Forbes


estimated that it could reach 20 billion USD by the year 2024.9


Obstacles and technical background While CBD may offer a solution to many disorders, its regulation is constantly evolving at global, federal, and state levels. Changes include, but are not limited to, the distribution, use levels, claims, and labelling of Cannabidiol itself, as well as of CBD-containing products. However, regulatory restrictions are not the only obstacles to the use of CBD. There are currently two types of CBD-containing ingredients that can be used in personal care: hemp oil and CBD isolate. Formulating a product containing CBD sounds at first like a relatively easy task, as both hemp oil and CBD isolate are oil soluble. However, hemp oil contains only minuscule amounts of CBD, and the activity


PERSONAL CARE April 2021


of the presented levels is questionable; the hemp oil concentration needed to produce the necessary quantities of CBD may therefore be exceptionally high, thereby ruining the texture and aesthetics of the final product. On the other hand, the use of CBD isolate in personal care products presents its own issues. CBD isolate is both very expensive and very concentrated. To guarantee a homogeneous distribution of the material, it must be properly dissolved in a suitable oil medium before being added to the final product, otherwise it will lack the ability to spread uniformly into a thin layer on the skin. Finally, the solubility parameters of CBD, whether in hemp oil or as a CBD isolate, are limited only to natural oils and hydrocarbons or glycols—preventing its compatibility with silicones and making its use in PDMS (polydimethylsiloxane) restrictive and therefore impractical. Since a substantial portion of both personal care and medical device products consist purely of silicone-based materials such as volatile silicones, silicone fluids, and silicone elastomers, the use of CBD in such products is therefore limited. The full potential of these applications—e.g., soft skin adhesives, scar reduction treatments, and transdermal patches, as well as anti-wrinkle and treatment face masks—is difficult to achieve with pure CBD or CBD isolate.


ABSTRACT


Cannabidiol (CBD) is widely used in the personal care industry and is frequently employed as an additive for moisturisers and topical products. However, CBD can be difficult to incorporate into purely silicone formulations—including volatile silicones, silicone fluids and silicone gels—due its lack of solubility. The rheology and surface energy of CBD also make it difficult to spread into uniform films on the skin. To address these barriers, Gelest has expanded its Vertasil® siloxane modified natural product line to include a new CBD- based derivative. This smart molecule, Vertasil TM-CBD1, specifically addresses formulation obstacles and limitations. As a CBD hybrid fluid, Vertasil TM- CBD1 has an expanded solubility profile that allows the incorporation of CBD into silicone-based products. It also provides lubricity and softness without the greasiness of natural oils. Finally, a distinctive benefit of this new technology is the ability of the CBD derivative to slowly revert back to pure CBD upon release from a silicone matrix.


www.personalcaremagazine.com


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