48 NATURALS
Natural matrikine-like peptides for skin rejuvenation
n B.Walzel,
T.Shah,
B.Senti, U.Bätz and S.Bänziger – Lipoid Kosmetik, Switzerland
Our skin is an integrated network of cells that communicate with each other using biological messengers - small molecules that carry information. Cellular signaling and cell-to-cell communication control e.g. inflammation, skin repair, melanogenesis or aging. Examples of signaling messenger molecules in skin are cytokines, neurotransmitters, growth factors, or matrikines, which freely diffuse between cells and transmit their messages, for example by binding to cell surface receptors.1
With age, the activity of
signaling and communication declines. This strongly affects the extracellular matrix impacting skin texture and topography.2
Synthetic matrikines and their use in cosmetics Matrikines are one type of dermal messengers that naturally occur in our skin. Matrikines are short peptides with defined amino acid sequences. Depending on their sequence, matrikines activate intracellular signaling pathways that lead to cellular events, such as cell proliferation, protein synthesis, or matrix formation.3,4 Matrikines promote ECM synthesis.
The extracellular matrix (ECM) consists of a network of interwoven macromolecules that give structure and elasticity to skin. Dermal fibroblasts are the factories of extracellular matrix proteins, producing collagen, elastin, or fibronectin. Matrikines regulate fibroblast activity by binding to specific receptors on their cell surface,
Figure 1: Lipoid Kosmetik’s technology produces natural matrikine-like peptides and makes them available for cosmetic applications. Proteases generate unique sets of short peptides from cedar nut proteins with an ideal average amino- acid chain length of about 4 amino acids, which were analyzed by mass spectrometry, de novo peptide sequencing. Using homology searches - matching original matrikine peptide sequences of our skin with cedar nut peptide sequences – we revealed several matrikine homologs (peptides with very similar sequences). Peptide sequences in the illustration are read from left to right using the amino acid 1-letter code.10
PERSONAL CARE NORTH AMERICA May 2020 Abstract
A person’s perceived age is determined by physical traits on face and neck. These traits mostly reflect the integrity of the extracellular matrix, which provides structure, homogeneity and elasticity to skin. Matrikines are dermal messenger peptides that instruct skin cells to reorganize and build
up the extracellular matrix. So far, synthetic matrikines have been used in cosmetics. Now, for the first time, Lipoid-Kosmetik AG investigated and isolated natural matrikines-like peptides from cedar nuts and presents them in a novel anti-aging concentrate: PhytoCodine® Here we show that plant-derived, matrikine-like peptides mimic the activity of matrikines
.
that naturally occur in our skin. Plant-derived, matrikine-like peptides activate the formation of extracellular matrix components, optimize skin structure, and improve age-related properties of mature skin, such as elasticity, density, wrinkles and sagging. Altogether, PhytoCodine®
is the first concentrate of plant-derived, natural matrikine-like
peptides. It reprograms fibroblasts to build up extracellular matrix components characteristic of younger looking skin and thereby directly contributes to a person’s perceived age.
250 200 150 100 50 0
1 3 5 7
9 11 13 15 17 19 21 23 25 Peptide Chain length
Number of Peptides
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96
