PDRN 83
8.00 7.00 6.00 5.00 4.00 3.00 2.00 1.00 0.00
Test value ** ***
Control value 5.21
14d 4.29 Figure 12: Skin firmness characteristic value F4
recombinant humanized elastin, recombinant design opens a route to biomimetic materials that would be extremely difficult to obtain in controlled form from natural sources.6 In our view, this points to a broader future
for cosmetic biotechnology. Instead of treating bioactive ingredients as vaguely defined extracts, formulators can increasingly work with programmable biomaterials whose structure, purity and biological profile are intentionally built. In anti-ageing, that shift may prove especially powerful because the skin deficits of ageing are themselves highly specific: not just damage, but defined losses in repair signalling, extracellular matrix organisation and tissue mechanics.
Conclusion For decades, anti-ageing development has focused heavily on collagen stimulation, antioxidants and surface hydration. Those approaches remain important, but they do not fully address the biological and structural
28d 2.91
120 100 80 60 40 20 0
Test value
***
***
Control value 69.09
14d 80.79 Figure 13: Skin elasticity characteristic value R2
complexity of aged skin. Recombinant PDRN and recombinant humanized elastin point to a more precise model of skin regeneration: one that supports repair pathways at the cellular level while also attempting to restore the elastic architecture that determines resilience, firmness and wrinkle behaviour. From a formulation perspective, both
materials also answer increasingly urgent industrial needs for safety, reproducibility and sustainable sourcing. As recombinant biomaterials continue to mature, we believe they are likely to move from niche innovation to a central role in performance-led skincare. From our perspective, the opportunity is not simply to replace animal- derived actives, but to redefine what regenerative cosmetic ingredients can be.
PCM
References 1. Veronesi F, Dallari D, Sabbioni G, Carubbi C, Martini L, Fini M. Polydeoxyribonucleotides (PDRNs) from skin to musculoskeletal tissue regeneration via adenosine A2A receptor involvement. J Cell
Physiol. 2017;232(9):2299-2307
2. Galeano M, Bitto A, Altavilla D, Minutoli L, Polito F, Calò M et al. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair Regen. 2008;16(2):208-217
3. Kim JK, Chung JY. The effects of polydeoxyribonucleotide on wound healing and scar prevention: a review. Int J Mol Sci. 2020;21(22):8433
4. Langton AK, Sherratt MJ, Griffiths CEM, Watson REB. A new wrinkle on old skin: the role of elastic fibres in skin ageing. Int J Cosmet Sci. 2010;32(5):330-339
5. Baumann L, Bernstein EF, Weiss AS, Bates D, Humphrey S, Silberberg M, Daniels R. Clinical relevance of elastin in the structure and function of skin. Aesthet Surg J Open Forum. 2021;3(3):ojab019
6. Wu K, Liu Z, Wang W, Zhou F, Cheng Q, Bian Y et al. An artificially designed elastin-like recombinant polypeptide improves aging skin. Am J Transl Res. 2022;14(12):8562-8571
28d 89.32
www.personalcaremagazine.com
September 2026 PERSONAL CARE MAGAZINE
F4 Value for Characterizing Skin Firmness
R2 Value for Characterizing Skin Elasticity
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