HAIR AND SCALP CARE 77 5 and 19 more hair per cm2 - after 42 and 84 days
of treatment respectively. Furthermore, the SiAd complex allowed for
a significant increase in hair thickness. This is consistent with the literature that states that hair thickness is dependent of the number of HFDPC,16 and that the SiAd complex stimulates HFDPC proliferation. Additionally, hair loss was also dramatically
reduced with hair more resistant to traditional combing (-16% and -48% hair loss after 42 and 84 days of treatment respectively) and gentle pulls (-31% and -56% hair loss after 42 and 84 days of treatment respectively). Taken together, these data suggest that the
SiAd complex is capable of stimulating hair growth while reducing hair loss thus leading to an increased hair density.
Conclusion The evolving paradigm of skinification in hair care recognizes the scalp as a dynamic and hormonally responsive tissue, which balance directly influences hair follicle homeostasis and hair fibre quality.1,4
Hair growth
Hair loss
B T0 T84
Total hair density (nbr of hair/cm2) % anagen
Hair thickness Hair count Pull test
A T42
Placebo +2.3*
+3.0%*
+0.5%*** -5.9%* -18.6%*
SiAd (5%) +4.6*Δ
+5.9%*Δ +1.0%*Δ -15.9%*Δ -31.0%*Δ
Placebo +10.3*
+4.0%* +1.0%*
-32.8%* -39.4%*
T84
SiAd (5%) +19*Δ
+8.1%*Δ +1.7%*Δ
-47.5%*Δ -56.3%*Δ
The
present study highlights the dual activity of a novel silicium–adenosine complex (SiAd). By targeting sebaceous gland activity and
hair follicles, the SiAd complex is capable of modulating sebum production while promoting hair growth in a minoxidil-like effect. Furthermore, and unlike pharmacological
agents such as minoxidil and finasteride, which are associated with side effects and poor compliance,15
the SiAd complex offers a well-
tolerated alternative to conventional therapies, with potential for daily topical application. Taken together, this work shows that the SiAd
complex is a multifunctional active ingredient that supports a scalp-centred approach to hair care innovation, and may be an interesting candidate for any hair and/or scalp care cosmetic solution.
References 1. Tobin DJ. Biochemistry of human skin— our brain on the outside. Chem Soc Rev. 2006;35:52–67
2. Cedirian S, Prudkin L, Piraccini BM, et al. The exposome impact on hair health: etiology, pathogenesis and clinical features – Part I. An Bras Dermatol. 2025;100:131–140
3. Picardo M, Ottaviani M, Camera E, Mastrofrancesco A. Sebaceous gland lipids. Dermatoendocrinol. 2009;1:68–71
4. Clayton RW, Langan EA, Ansell DM, et al. Neuroendocrinology and neurobiology of sebaceous glands. Biol Rev Camb Philos Soc. 2020;95:592–624
5. Grymowicz M, Rudnicka E, Podfigurna A. Hormonal effects on hair follicles. Int J Mol Sci. 2020;21:5342
6. Lino M, Ehama R, Nakazawa Y, et al. Adenosine stimulates fibroblast growth factor7 gene expression via adenosine A2b receptor signaling in dermal papilla cells. J Invest Dermatol. 2007;127:1318–1325
7. Li M, Marubayashi A, Nakaya Y, et al. Minoxidilinduced hair growth is mediated by
www.personalcaremagazine.com Digital Pictures
PCM
Phototrichogram
Figure 6: The SiAd complex stimulates hair growth and reduces hair loss in women affected with telogen effluvium. Thirty-five women with telogen effluvium received a daily treatment with the SiAd complex (5%) or placebo for 84 days. (A) Hair growth was assessed with phototrichogram while hair loss was assessed using shedding and pull test assays. *p-value<0.05, ***p-value<0.001 versus T0., Δp- value<0.05 versus placebo. (B) Digital and photoscan photographs of representative volunteers before and after the treatment
adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001;117:1594–1600
8. Kim YM, Kwon SJ, Jang HJ, Seo YK. Rice bran mineral extract increases the expression of anagenrelated molecules in human dermal papilla through Wnt/catenin pathway. Food Nutr Res. 2017;61:1412792
9. Araújo LA, Addor F, Campos PMBGM. Use of silicium for skin and hair care: an approach of chemical forms available and efficacy. An Bras Dermatol. 2016;91:331–335
10. Lassus A. Colloidal silicic acid for the treatment of seborrheic disorders. J Int Med Res. 1997;25:277–281
11. Varothai S, Bergfeld WF. Androgenetic alopecia: an evidencebased treatment update. Am J Clin
Dermatol. 2014;15:217–230
12. Géhin C, Tokarska J, Fowler SJ, Barran PE, Trivedi DK. No skin off your back: the sampling and extraction of sebum for metabolomics. Metabolomics. 2023;19(4):21
13. Asfour L, Cranwell W, Sinclair R. Male androgenetic alopecia. 2023 Jan 25
14. Sinclair R. Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness. Br J Dermatol. 2011;165(Suppl 3):12–17
15. Rossi A, Mari E, Scarnò M, et al. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov. 2012;6:130–136
16. Chi W, Wu E, Morgan BA. Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline. Development. 2013;140(8):1676–1683
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