LONGEVITY 71
confidence—delivering powerful, holistic results inspired by nature and backed by cutting-edge biotechnology. InnovaBioTech Haberlea and InnovaBioTech
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Gene expression (time fold)
2% Exosome-rich extract
PCM
References 1. Wong QYA, Chew FT. Defining skin aging and its risk factors: a systematic review and meta- analysis. Sci Rep. 2021;11(1):1–13
2. Georgieva M, Vasileva B, Ivanov P, Hristova- Panusheva K, Paunova-Krasteva T, Lesov I et al. Cosmetic Potential of Haberlea rhodopensis Extracts and Extracellular Vesicles in Human Fibroblast Cells. Cosmetics. 2025;12(3):90
3. Peeva MI, Georgieva MG, Balacheva AA, Pavlov A, Tzvetkov NT. In Vitro Investigation of the Cytotoxic and Antiproliferative Effects of Haberlea rhodopensis Total Extract: A Comparative Study. Cosmetics. 2024;11(2)
4. Thakur A, Shah D, Rai D, Parra DC, Pathikonda S, Kurilova S, et al. Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases. Cosmetics. 2023;10(2):1–14
5. Rutter BD, Innes RW. Extracellular vesicles isolated from the leaf apoplast carry stress-response proteins. Plant Physiol.
2% Exosome-rich extract
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Figure 9: RT-qPCR analysis of the effects of 2% exosome-rich extract for 24h and 72h on the expression of age-related genes (COL3A1, COL3A3, CDKN1A, and NFE2L2) in BJ cells. Adapted from: Georgieva M, Vasileva B, Ivanov P et al. Cosmetic Potential of Haberlea rhodopensis Extracts and Extracellular Vesicles in Human Fibroblast Cells. Cosmetics. 2025;12(3):90. doi:10.3390/ cosmetics12030090
2017;173(1):728–41
6. Villarreal-Gómez LJ, Origel-Lucio S, Hernández-Hernández DA, Pérez-González GL. Use of Exosomes for Cosmetics Applications. Cosmetics. 2025;12(1)
7. Martic I, Papaccio F, Bellei B, Cavinato M.
Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging. Front Physiol. 2023;14(November):1–17
8. Tan JX, Finkel T. Lysosomes in senescence and aging. EMBO Rep. 2023;24(11):1–20
NFE2L2 ■ CDKN1A ■ COL3A1 ■ COL1A1 ■
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