74 A


HAIR AND SCALP CARE B 120 100 -22% * 80 *** 60 40 20 0 Untreated Control Cerulenin Lipogenic mix + DHT


Figure 2: The SiAd complex inhibits sebum production in sebocytes. Sebocytes were exposed to a lipogenic mix coupled with DHT in the presence or in the absence of cerulenin or SiAd. The amount of lipid produced was observed (A) - lipid droplets appear in green and nuclei in blue - and quantified (B). Mean ± SEM. *p-value<0.05, ***p-value<0.001 versus control


absence of cerulenin (a lipid synthesis inhibitor reference) or the SiAd complex (0.3%) (Figure 2). While exposure to LM+DHT dramatically


increases lipid production by cultured sebocytes. The addition of cerulenin leads to a decrease in lipid overproduction. The SiAd complex also significantly inhibits LM+DHT-induced lipid overproduction (-22% versus control) and may


A SiAd (5%) ■ Placebo ■


105 100 95 90 85 80 75


T0 C


105 100 95 90 85 80 75


T0 * -7% *** *** *** -12%


therefore contribute to normalizing sebum production on both skin and scalp. This in vitro effect was confirmed in a clinical


study where 80 volunteers received a topical application of a cream containing 5% SiAd complex or a placebo twice a day for 28 days (Figure 3). A significant reduction in skin sebum content was observed as early as Day 14.


C The volunteers showed a 7.4% and 12.2%


reduction in sebum quantity compared to baseline (T0) after 14 and 28 days of treatment respectively, with a statistically significant difference compared to placebo at all times (Figure 3A). Skin appearance after 14 and 28 days of


treatment was clearly less oily than at baseline (Figure 3C). Interestingly, similar results were observed


on the scalp of volunteers who applied a lotion containing 5% SiAd complex once a day, with a 7.1% and a 11.2% reduction in sebum quantity after 14 and 28 days of treatment respectively (Figure 3B). This suggests that the SiAd complex could reduce oily hair and residues (e.g. flakes, dandruff) which was indeed observed by the volunteers themselves (data not shown). Beyond its effects on sebum production on both face skin and scalp, the impact of the SiAd co


T14 *** * -7% ***


-11% ***


T28 *** ** T14 T28


Figure 3: The SiAd complex reduces oily skin and scalp in vivo. Clinical study performed on 80 volunteers who received a daily treatment with the SiAd complex or placebo for 28 days. Sebum content was measured on the face (A) or on the scalp (B) using a sebumeter. (C) Pictures of sebum reduction on skin. Mean ± SEM. *p-value<0.05, **p-value<0.01, ***p-value<0.001 vs T0 (or versus placebo)


PERSONAL CARE MAGAZINE September 2026


Promoting hair growth while reducing hair loss in a Minoxidil-like way Hair follicle has a ‘permanent zone’ composed of the hair sheath, the sebaceous gland and the arrector muscle, and ‘cyclic zone’ that comprises the bulb which undergoes a cyclic pattern composed of three phases: Anagen (growth), catagen (regression) and telogen (quiescence). The bulge is located at the interface between the permanent and cycling zones. It contains hair follicle stem cells that will migrate through the outer root sheath toward the hair dermal papilla and initiate the transition between the telogen (quiescent phase) and the anagen (growth phase) phases (Figure 1). During the anagen phase the stem cells will


proliferate and differentiate around the dermal papilla to form the hair matrix cells (mostly


www.personalcaremagazine.com SiAd (0.3%)


Sebum content in scalp (% of T0)


Sebum content in skin (% of T0)


Lipid quantity (% of control)


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