MENOPAUSAL SKIN CARE 27 D0 D28 D0 D28


Figure 4: Reduced wrinkle depth. Images taken under standard lighting mode Figure 5: Enhanced radiance. Images taken under standard lighting mode


Glutathione without synthetic byproducts, enables precise control over molecular structure and purity, and achieves 88% natural origin classification. The ingredient is vegan and additive-free, addressing the clean beauty expectations of contemporary consumers. From a supply chain perspective, precision


fermentation offers scalability and reproducibility. The process reduces dependence on chemical synthesis, ensures consistent quality and traceability, and represents a sustainable, fermentation-based manufacturing approach that aligns with industry trends toward biotechnology. Regulatory advantages are equally compelling:


the natural origin and fermentation-based production support clean beauty positioning and consumer trust, while facilitating global regulatory compliance across diverse markets. We investigated the effect of SAG as a


cosmetic active ingredient on the hallmarks of ferroptosis in skin cells, as well as on the improvement of several skin parameters in a placebo-controlled clinical study, to determine its potential to improve skin health in post- menopausal women.


Interrupting the ferroptosis cascade To assess its biological relevance, S-Acetyl Glutathione was evaluated in several in vitro models mimicking glutathione depletion or oxidative stress conditions. In an in vitro ELISA assay, the active was proven to outperform standard GSH in restoring glutathione levels in human keratinocytes after GSH depletion with Buthionine SulfOximine (BSO) (Figure 1). S-Acetyl Glutathione also exhibited a -39%***


reduction of malondialdehyde, an end-product of lipid peroxidation, in human keratinocytes under BSO stress (Figure 2). This result is particularly relevant in the context of ferroptosis, where toxic lipid peroxide accumulation is a defining feature. By slowing down the accumulation of lipid peroxides, SAG can help preventing the ferroptotic cell death. Ferroptosis is closely related to mitochondrial function, as mitochondrial dysfunction and damage promote ROS production and oxidative stress. In vitro data demonstrate S-Acetyl Glutathione’s protective efficacy in those cellular energy centers, exhibiting a +88%** improvement in mitochondrial network integrity in human


fibroblasts in basal conditions and +245%** under oxidative stress conditions (Figure 3). Additional oxidative protection was shown


trough reduction of protein carbonylation, an irreversible damage, as treatment with the active reduced by 68%*** the protein carbonylation in human keratinocytes (in vitro carbonylation evaluation after 24-hour BSO stress exposure. 24- hour pre-treatment with 0.05% SAG. ***p<0.001). Carbonylated proteins accumulation within the


stratum corneum is also linked to the loss of skin moisture functions, an important clinical sign in menopausal women. These actions—supporting mitochondrial health and preventing protein damage—help to support cellular resilience and counteract the functional decline that underpins hormonal ageing. Together, these results provide a useful view


of how the ingredient supports redox resilience in stressed skin cells.


The pro-longevity potential of S-Acetyl Glutathione SAG’s activity extends to hallmarks of biological ageing, such as chronic inflammation and ECM


www.personalcaremagazine.com


September 2026 PERSONAL CARE MAGAZINE


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