EYE AREA CARE
Biohacking sleep for a restored eye area
M. Mateu, P. Carulla, M.J. Klein, A. Grau-Campistany, S. Pastor, M. Llinàs - Lipotrue, Spain
It is well known that an adequate amount and quality of sleep is key to repairing the damage inflicted to the body during the day. However, it is difficult to really enjoy a regularly undisturbed sleep of 7-9 hours per night. A survey conducted among adults in 13
countries revealed that on average, people sleep 6.8 hours per weeknight and 7.5 hours per weekend night. Hence, the amount of sleep lost during the working week is not compensated over the weekend. Moreover, only 49% of adults are satisfied with their sleep. The recent COVID-19 pandemic has only
worsened our sleep quality. Another recent survey among US adults displayed that 98% have developed new sleep problems, and 68% feel it is harder to sleep even after measures were lifted. An additional survey showed that 60% of adults are interested in strategies to sleep better, what is known as biohacking sleep. Sleep deprivation is associated with
chronic low-grade inflammation, oxidative stress, impaired immune response, reduction of melatonin levels, and higher glucose levels. All of them induce more oxidative stress and inflammation, resulting in: ■ Hanging eyelids (sagging) & wrinkles: due to protein glycation of the ECM ■ Dark circles: the bluish colour comes from the leakage of the coloured substances of the endothelial vessels (glycation), the yellowish colour from lipid peroxidation of the epidermis, and the brownish colour comes from the brown colour of the AGEs and from hyperpigmentation due to post-inflammatory melanogenesis. Inflammation can lead to neovascularization, so an excess of capillarity under the thin skin of the eyes can also provide a bluish-violet coloration. ■ Eyebags: deterioration of lymphatic integrity (glycation), which is not able to drain and
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remove waste and inflammatory substances ■ Warmth sensation due to the inflammation ■ Compromised immune system: epidermal barrier is compromised (glycation and lipid peroxidation), low clearance of toxic substances by the lymphatic system (glycation)
A new tool to ‘biohack’ sleep Through a Big Data analysis, LipoTrue has discovered iPeptide™, which modulates the exaggerated inflammatory response of the alarmin IL-33, acts as a melatonin-like, and protects skin’s proteins from glycation due to hyperglycemia because of a bad quality of sleep. iPeptide (Acetyl Hexapeptide-8) has been
developed as a solution to biohack your sleep, which has demonstrated to be an excellent candidate in fighting all the main pillars of lack of sleep.
Efficacy studies Opening the eyes Twenty-four women (50-64 years old sleeping 5-6 hours per day) applied a cream containing 3% Acetyl Hexapeptide-8 around one eye twice daily for 28 days. A placebo was applied around the other eye. The results from this study showed a 9% increase in eye awakening in 68% of volunteers after one month, a 5% reduction in fatigue in one week, and a 7% reduction in eyebags vs placebo after 2 weeks (Fig 1).
Attenuation of inflammation In a study, Acetyl Hexapeptide-8 was shown to modulate the exaggerated inflammatory response of alarmin IL-33, which has ST2 as its receptor. In the study, the ingredient demonstrated a dose-dependent effect, with 0.05 mg/mL of Acetyl Hexapeptide-8 (which
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corresponds to 10%), delivering a reduction of a 63% of IL-33 released. The inflammation has a direct effect on the sensation of skin temperature. An in vivo study was conducted on 22 men (aged 34-50 years old) who applied a cream containing 3% Acetyl Hexapeptide-8 around the eyes twice daily for 28 days. Using an infrared camera, the local skin temperature was measured after 1 hour showing a 0.96°C reduction in 91% of volunteers. Dark circles were also assessed, recording a 12% reduction in 7 days and 19% in 28 days.
Prevent damage caused by glucose levels Hyperglycemia increases the formation of advanced glycation endproducts (AGEs), which have a detrimental impact on skin health, increasing skin ageing. For the purposes of the study, carboxymethyl lysine was used as a marker to identify the formation of AGEs in the presence of Acetyl Hexapeptide-8 on human skin explants (40 years old). It was demonstrated that 1% Acetyl Hexapeptide-8 reduced the area occupied by AGEs by 73% compared to the untreated explant and by 56% compared to placebo. AGEs can also negatively affect the
integrity of the skin. Fibrilin microfibrils constitute a scaffold for elastin deposition in elastic fibres and in the wall of endothelial vessels. They also form the anchoring filaments that connect the lymphatic endothelium to surrounding elastic fibres. In a study it was shown that integrity
reinforcement (measured by the surface occupied by fibrillin-1 on a human skin explant) was increased by 86% in the presence of 1% Acetyl Hexapeptide-8 compared to non- treated explants.
EYE AWAKENING IN 28 DAYS (%) 9%
59
3% 1% Placebo Figure 1: Eye-opening effect.
www.personalcaremagazine.com May 2021 PERSONAL CARE iPeptide iPeptide (68% responders)
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