42 HYGIENE
Clinical evaluation In vivo 1: Dysbiosis rebalance The first clinical trial was carried out with a panel of acne-prone skin volunteers (12-29 years old) where the number of skin microbial cells were quantified. The results showed that the active reduced the relative proportion of virulent bacteria (S. aureus and C. acnes), while maintaining the most beneficial microbial population of the skin (S. epidermidis). This in vivo test shows that the active
ingredient rebalances the microbiota of acne- prone skin, respecting the most beneficial commensal bacteria (Fig 5).
Reduction of sebum level production To measure the levels of production of sebum, a Sebumeter SM815 was used, and the measures were taken on the forehead of the volunteers. Results show that the active significantly decreased the sebum production down to 28% at 30 days. The sebum levels went down going from an average value considered oily skin to normal skin in means of skin sebum.
Pore size reduction To measure the area with pores, the sophisticated technique Visioface® 1000D was used. The active decreased the area with pores by 48% on average, compared to placebo, reaching up to 92% reduction in the best case (Fig 6).
Dermatologic evaluation of acne lesions and HD-visioface Macrographies To evaluate the effect of the active in acne lesions, the Spanish Scale of Acne Gravity (Escala de Gravedad del Acné Española – EGAE) was used, and physical examinations were done by a dermatologist, using a visual scale to determine the intensity and scope of the lesions. 3 grades of acne were used (soft, moderate, and severe), and the evolution of comedones was evaluated. The plant stem cell-derived active reduced
T0D Figure 6: Pore decrease.
the presence of open comedones by -15% on average compared to placebo, reaching up to -80% in the best case. These data and the macrophotographies taken with HD-visioface (Fig 7) demonstrate the ability of the ingredient to reduce the number of lesions caused by acne, and to perfect skin surface.
Conclusion The active ingredient Quora Noni™ brings a new mechanism of action against acne, blocking the microbial Quorum Sensing. By hacking their communication system, bacteria are not able to form biofilms and turn virulent, which prevents from the formation of acne and other skin disorders related to microbiome.
VOL.14 Quora Noni is recommended both for the
treatment and prevention of acne, as well as the treatment of hair and scalp problems such as dandruff or sensitive and greasy scalp. Since it does not contain antibiotics, and its bacteriostatic properties, the potential generation of resistance by bacteria is avoided, which is usually common in other acne treatments. Made from plant stem cells, Quora Noni
addresses acne-prone skin care in a way that respects the skin microbiota, representing a natural and highly efficient treatment. A revolutionary mechanism of action, in line with the demand for Clean Beauty cosmetics by consumers and an ally against maskne.
T30D Placebo QUORA NONI
PC
Figure 7: HD-Visioface Macrophotographies. PERSONAL CARE May 2021
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