NEWS
3D model mimics acneic skin
The advanced research teams of Silab Softcare have developed a 3D in vitro model of reconstructed epidermis that mimics acneic skin. Most 3D models mimicking acneic skin independently use hyperseborrhea or invasion by C. acnes to induce the characteristics of acneic skin. However, as these two factors are inter-related at the early stages of the pathology, the aim of this work was to develop a 3D model combining sebum alteration and invasion by C. acnes. In this model, reconstructed epidermis was treated simultaneously with peroxidised squalene and C. acnes phylotype IA1 obtained from culture collection or isolated directly from acneic patients. The combination of these two factors induces acne-like
keratinocyte responses, such as hyperkeratinisation and inflammation, thereby providing a model exhibiting all the characteristics of acneic skin. The 3D model resulting from this
work has enabled the company to demonstrate the pharmacological activities of Acnesium, a natural active ingredient developed by Silab Softcare to treat the clinical signs of slight to moderate acne in adults. Produced from the pericarps of
immature pomegranates, Acnesium restores homeostasis to acneic skin by targeting the four major components of this pathophysiology: it restores sebaceous gland activity to normal, controls colonisation by C. acnes phylotype IA1, has a keratolytic action and reduces inflammation.
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Synthetic eugenol introduced
Solvay introduces Eugenol Synth, an innovation for fragrance applications with olfactory properties comparable to that derived from cloves. The new high purity synthetic eugenol will provide a reliable alternative to help meet Flavors & Fragrance (F&F) market demand for applications for which natural origin is not essential. Solvay has developed a
robust and competitive process to produce synthetic eugenol to offset the quality, supply and price fluctuations occurring in the sourcing of natural eugenol extracted from cloves. “Solvay strategically extends
its aroma chemicals portfolio pushing the boundaries with
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a commitment to innovate and anticipate F&F market expectations,” said Corinne Duffy, technical marketing manager & Eugenol project manager at Solvay Aroma Performance. “Thanks to our back integration in guaiacol, a key intermediate in our diphenol chain, our R&I teams have been able to develop an innovative process successfully scaled up to produce synthetic eugenol.” Eugenol derived from cloves,
is an aromatic flower spice used widely across flavour (food and beverage) and fragrance applications. Because of its analgesic and antiseptic properties, it is also used in oral care formulations such as toothpastes and mouthwashes.
March 2021 PERSONAL CARE
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