34 ANTI-AGEING D0, before treatment
D14, after treatment with Pichia Ferment Lysate Filtrate at 1.7%
D0, before treatment
D56, after treatment with Pichia Ferment Lysate Filtrate at 1.7%
Reflection: +
Reflection: ++
Reflection: +
Reflection: +++
Figure 4: Visualization of the effect of the Pichia Ferment Lysate Filtrate on the complexion radiance of Caucasian (left) and Asian volunteers (right) After 42 days of application, the active
ingredient significantly improves the appearance of wrinkles and skin tone. In addition, visual assessment by trained evaluators showed a significant improvement of parameters of overall appreciation of complexion radiance: skin grain is refined, and the complexion is fresher and more radiant. After using the Calendula officinalis Flower
Extract, the face looks younger with a visible healthy-glow effect (Figure 6). 75% of volunteers considered that the formula containing the active ingredient reduces their expression wrinkles and improves their skin’s firmness. Silab made optimal use of the
oligosaccharides of Calendula officinalis to develop Epigenomyl®. Ancient populations believed that marigolds could transform the skin, rendering it radiant and brimming with vitality.
Conclusion Consumers pay attention to the long-term health of their skin and so are increasingly
D0 Normal explant SSR explant
Control
Control
Organization of fibres: +++
0.25% Calendula officinalis Flower Extract
Organization of fibres: +++
Figure 5: Effect of the Calendula officinalis Flower Extract on the organization of elastin and fibrillin-1 fibres in explants of human skin after repeated solar aggressions
attracted by preventive approaches at the same time as realizing that ageing is neither a disease nor an abnormal phenomenon. Science is constantly advancing and
so enables this scope of action to be continually broadened while the hallmarks help to establish a universal definition of
D42
ageing. Silab’s expertise in skin biology has enabled it to demonstrate the role of certain pathways and key markers in the process of biological ageing and has developed natural active ingredients capable of acting on these essential players to sustain longevity of the skin.
1.00% Calendula officinalis Flower Extract
PC
References 1. World Health Organization. Global Health Estimates: Life expectancy and healthy life expectancy.
https://www.who.int/data/gho/ data/themes/mortality-and-global-health- estimates/ghe-life-expectancy-and-healthy- life-expectancy
2. Roland Berger. Future of health 5 - A long and healthy life. 8 November 2023 https://
www.rolandberger.com/en/Insights/ Publications/Future-of-health-5-A-long-
and-healthy-life.html
3. McKinsey & Company. What’s new in consumer wellness trends? 16 May 2024.
https://www.mckinsey.com/industries/ consumer-packaged-goods/our-insights/ whats-new-in-consumer-wellness-trends
Figure 6: Anti-ageing effect of the Calendula officinalis Flower Extract formulated at 3% in an emulsion PERSONAL CARE June 2025
4. Cosmetics Design USA. Revolutionizing beauty: How longevity science is transforming skin care.
https://www.cosmeticsdesign.com/ Article/2024/05/23/revolutionizing-beauty- how-longevity-science-is-transforming-skin- care/
www.personalcaremagazine.com
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