AI
AI: cracking the code of youth
Coralie Ebert, Bat-Chen Tamim, Hilla Ben-Hamo – MeNow
Sirtuins, particularly SIRT1, play a crucial role in cellular health, ageing, and longevity.1
This
protein regulates cellular senescence, a process in which cells lose their ability to divide, contributing to skin ageing. SIRT1 also enhances DNA repair mechanisms and is essential for maintaining the skin barrier by influencing the expression of key proteins like filaggrin.2
This
makes SIRT1 a highly sought-after target in anti- ageing skin care and dermatological research. Comparatively, the retinoic acid pathway,
activated by retinoids such as retinol and tretinoin, is one of the most well-known strategies for skin renewal and reversing signs of ageing.3
cell turnover, regulating pigmentation, and controlling sebum production, making them highly effective for improving skin texture, tone, and acne-prone conditions.4 Both SIRT1 activation and the retinoic acid
pathway contribute to reducing inflammation, mitigating oxidative stress, and preserving the extracellular matrix (ECM) by supporting collagen production, reinforcing skin structure and elasticity. However, while retinoids can cause irritation, peeling, and sensitivity, making them unsuitable for some individuals, SIRT1 activation offers a promising alternative—instead of forcing the skin to regenerate rapidly like retinoids, it enhances the skin’s intrinsic ability to repair, maintain barrier function, and combat oxidative stress at a cellular level (Figure 1).
Traditionally, resveratrol has been hailed
as the gold standard for SIRT1 activation.5 However, groundbreaking AI-driven research from MeNow has revealed that resveratrol might just be a lightweight in comparison to the potent molecules uncovered by their advanced technology. This marks a new era in skin care, where reversing ageing isn’t about simply exfoliating or stimulating collagen but optimizing cellular longevity itself.
The power of AI in natural bioactive discovery The need for AI in ingredient discovery has never been greater. Despite nature’s vast biochemical complexity, less than 1% of natural compounds have been fully characterized, leaving an immense reservoir of untapped potential. Traditional in vitro methods for ingredient discovery have reached their limits due to the sheer number of molecules that would need to be tested, making comprehensive exploration impractical. AI is changing the game by offering rapid,
Collagen Pigmentation Production
Senescence prevention
Mitochondrial Biogenesis
ECM Retinoic Pathway Cell Turnover Anti- Inflammatory DNA repair Sebum Regulation Longevity
Oxidative stress Reduction
www.personalcaremagazine.com Figure 1: Main mechanisms of action (MOAs) of SIRT1 activation and the retinoic pathway in skin health
Preservation SIRT1 Pathway
data-driven screening of compounds with specific biological targets, such as SIRT1 activation. The pharmaceutical industry has been leveraging AI for decades to accelerate drug discovery, reduce failure rates, and optimize molecular formulations. Now, the same principles are being applied to cosmetics, where AI can predict bioactivity, optimize molecular interactions, and identify safe, effective, and sustainable ingredients faster than ever before.6 One of the leaders in the field, MeNow has
developed a revolutionary AI-driven approach that accelerates the discovery of bioactives using its patented technology. This system integrates QSAR modeling and Deep Bayesian Networks to scan and predict the activity of molecules from natural sources (Figure 2). QSAR (Quantitative Structure-Activity
June 2025 PERSONAL CARE Retinoids work primarily by accelerating
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