ANTI-AGEING


profit from the natural high protein content of the yeast Pichia stipitis. Obtained from a collection and cultivated in-house in the biotechnologies unit, this yeast complies with the company’s requirements for traceability and the sustainability of raw materials. Obtained using a process combining enzyme engineering and purification, Commusys® is purified to more than 90% in biopeptides.


Epigenetics Epigenetics is a set of mechanisms capable of regulating the expression of genes without modifying the DNA sequence. This branch of science proposes explaining the influence of the environment on the expression of our genes. It involves a number of biological mechanisms including DNA methylation, modification of histones and the expression of miRNAs, non- coding RNAs that can repress the expression of specific genes. Using a transcriptomics approach jointly


with University of Toulouse III, an active ingredient was developed that limits age- related modifications of the epigenome, thereby enabling the organism to adapt to stress and limit skin ageing (Calendula officinalis Flower Extract). It protects keratinocytes from age-related hypomethylation of DNA, prevents modification of histones and regulates the production of miRNAs. As a result of this mechanism of action, the organization of elastin and fibrillin-1 is preserved and procollagen I synthesis is revived (Figure 5).


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Inhibitors of regeneration pathways


Inhibitors of proliferation pathways


Inhibitors of barrier function/ differentiation pathways


Figure 3: Capacity of the Pichia Ferment Lysate Filtrate to limit the expression of miRNAs in extracellular vesicles (EV) secreted by aged fibroblasts


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June 2025 PERSONAL CARE


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