74
ANTI-AGEING
120 100 80 60 40 20 0
100
reduction 90
10%
reduction **
78 22% reduction ** 63
*** 52
*** 5
125 Basal Ctrl. 250 NeoC101TM Figure 5: Diascorbyl azelate reduces UVB-induced ROS generation
accumulates, collagen synthesis declines, and its degradation accelerates, leading to wrinkles and sagging. Diascorbyl azelate not only prevents oxidative
damage to collagen but also promotes collagen synthesis, particularly Collagen Type I, the most abundant form found in the dermis. Diascorbyl azelate has been shown to stimulate collagen type I synthesis at protein level by up to 164% (Figure 6). This helps restore dermal density and resilience, counteracting visible signs of ageing by supporting the extracellular matrix and promoting skin rejuvenation from within.
Diascorbyl azelate: a revolutionary solution for oxy-stress defence The impact of oxidative stress extends far beyond superficial skin concerns—it is a constant, underlying biological process that affects both skin health and overall well-being. While this article focuses on its effects on the skin, it is important to recognize that antioxidants play a systemic role in protecting cells from long-term damage caused by reactive oxygen species (ROS). Unlike conventional antioxidants that only
neutralize ROS temporarily, diascorbyl azelate delivers a next-generation solution by integrating three synergistic antioxidant pathways into a
single molecule, alongside multifaceted benefits for photoprotection, inflammation, and visible skin imbalances: Direct radical scavenging - diascorbyl azelate
rapidly neutralizes free radicals to protect vital cellular structures like DNA, lipids, and proteins— offering fast-acting defence similar to traditional Vitamin C. Mitochondrial protection - diascorbyl
azelate helps sustain mitochondrial function by supporting the activity of superoxide dismutase 2 (SOD2), a key enzyme that converts harmful superoxide radicals into less reactive molecules— addressing oxidative stress at its source. Gene-Level Antioxidant Activation -
diascorbyl azelate promotes the expression of heme oxygenase-1 (HMOX1), an Nrf2-regulated enzyme known for breaking down pro-oxidant heme and generating cytoprotective byproducts. This helps reinforce the skin’s endogenous defence systems and builds long-term oxidative resilience. Together, these three mechanisms work
in harmony—delivering a smarter, more comprehensive defence system that goes beyond ROS neutralization, enabling skin to actively resist oxidative stress and recover from it more effectively.
300 250 200 150 100 50 0
264 *
Conclusion Diascorbyl azelate is more than just a Vitamin C derivative, it is a strategic upgrade in antioxidant science. Think of it as an evolved defence system: it neutralizes free radicals instantly like Vitamin C, but also continues working beneath the surface, supporting the skin’s energy systems and cellular defences over time. This continuous, layered protection helps reduce ROS accumulation, maintain mitochondrial health, promote collagen production, and enhance visible skin clarity, resilience and radiance. At Corum, we believe your skin deserves
more than surface-level protection. NeoC101 was developed to tackle the root causes of oxidative ageing, empowering the skin from within and revealing a complexion that looks clearer, stronger, and more luminous in day after day.
References 1. Chandimali N, Bak SG, Park EH, Lim HJ, Won YS, Kim EK, Park SI, Lee SJ. Free radicals and their impact on health and antioxidant defenses: a review. Cell Death Discov. 2025 Jan 24;11(1):19
2. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull. 1993; Jul;49(3):481-93
3. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763
4. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005; 120(4), 483-495
5. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules. 2015; Apr 21;5(2):545-89
100
6. Cathcart RF. A unique function for ascorbate. Med Hypotheses. 1991; May;35(1):32-7
7. Pullar JM, Carr AC, Vissers MC. The roles of vitamin C in skin health. Nutrients. 2017; 9(8), 866
8. Oresajo C et al. The role of oxidative stress in acne and rosacea. Journal of Drugs in Dermatology, 11(6). 2012; 734–738
Control Figure 6: Diascorbyl azelate stimulates collagen type I synthesis PERSONAL CARE MAGAZINE March 2026 Diascorbyl Azelate 1 ppm
9. Kircik LH. Advances in the understanding of the pathogenesis of inflammatory acne. Journal of Clinical and Aesthetic Dermatology. 2011; 4(9), 30–36
www.personalcaremagazine.com 500 (ppm) 1000 125 250 500 Ascorbic Acid (ppm) 1000 37% reduction 75 * ** 66
*** 54
*** 45
48%
PCM
Collagen Type I Protein (% of Ctrl)
ROS generation (% of Ctrl)
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