66 SKIN MICROBIOME
Rebalancing skin microbiota for sensitive skin
Giorgio Carelli – Roelmi HPC
The primary role of the skin is to serve as a physical barrier, protecting our bodies from potential assault by foreign organisms or toxic substances. One factor that determines good skin functioning is a properly working skin microbiota. The skin is also an interface with the outside
environment and, as such, is colonized by a diverse collection of microorganisms.1
This
complex set of microorganisms consists of bacteria, fungi, viruses, micro-eukaryotes (mites), archaea and phages.2 The perception of the skin as an ecosystem,
composed of living biological and physical components occupying diverse habitats can advance our understanding of the delicate balance between host and microorganisms. Perturbations affecting the host
microorganisms relationship can be endogenous (for example, genetic variation that selects for a specific microbial community) or exogenous.3 There are diverse mechanisms of skin immune
system support that are associated with the activity of the microorganisms. One of these is the colonization of the skin surface, preventing expansion by pathogens.4 While a properly functioning microbiota
of healthy skin supports the body’s immune barrier, its transition into a dysbiosis state may lead to numerous disorders. Dysbiosis, which is a disturbance of the structural and functional balance of the normal microbiome, is caused by internal and external stressors.5 The utilization of postbiotics in cosmetics
application, for the restoration of skin microbiota, is increasing across different regions at global level. Postbiotics are deactivated bacterium, that represent the exclusive viable form applicable in cosmetic formulations. This preference arises from their inclusion
of preservative system essential for neutralizing microorganisms, a capability absent in probiotic variants.
Origin and composition EquiBiotics LA (INCI name: Maltodextrin, Lactobacillus) is derived from L. acidophilus PBS067, a probiotic bacteria owned by Synbalance, a Roelmi Group company. Through careful phenotypic and genotypic selection, it has been identified a strain with proven beneficial properties, safety profile (QPS status from EFSA) and performance. From a highly researched, effective, and safe
PERSONAL CARE MAGAZINE March 2026
probiotic, Roelmi HPC has developed, through tyndallization, a new postbiotic that is part of a broader platform with cutting-edge technology in which this specific ingredient stands out for its protection, balance, and visible skin health. The production process is the result of
the synergy of two distinct types of scientific expertise. On one side, a biotechnological reality able to handle the identification, isolation, application, clinical trials, and industrialization. On the other hand, a green chemistry one
that developed the controlled fermentation, tyndallization, and all efficacy tests on the marketed ingredient. To complete the ingredient, the inactivated microorganisms were dispersed in a food-grade excipient (maltodextrin), thus preserving its application safety.
In vitro tests
Based on its origin, the safety of the postbiotic is a key point in the development of the raw material. In addition to the QPS (Quality Presumption of Safety) status from the European Food Safety Authority (EFSA), the cosmetic ingredient is safe both at the ocular level – in vitro eyes irritation OECD 492, and at the dermal level – in vitro skin irritation OECD 439 MTT Test, in vitro skin sensitization HRIPT. These results confirm the safety of the
ingredient and support its topical application on sensitive skin affected by dysbiosis.
ABSTRACT
The study aims at presenting a particular innovative approach to rebalancing the skin microbiota by benefiting the skin and preventing its alterations. Through a soft process the bacteria are inactivated but retains all the beneficial actions toward our skin. Equibiotics® LA is able to rebalance microbiota for both babies and adults with a specific focus on sensitive skins
Ex vivo tests Sensitive skin is generally defined as reduced tolerance to frequent and prolonged use of cosmetics and toiletries.6,7
and younger look, people tend to use a great number of cosmetics and care products. In response to these changes, subjects
complaining of sensitive skin are on the rise.8,9 Many epidemiological surveys revealed that prevalence of sensitive skin is very high, i.e. approximately 50% of the general population.8–10 Despite the widespread nature of sensitive
skin, a single definition of this condition remains obscure. The pathogenesis of sensitive skin is, at present, poorly understood.9 Recently, some investigators suggested that
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Patients usually suffer
from irritation and unpleasant sensation with facial erythema.8
As concerns grow about beauty
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