68 SKIN MICROBIOME
assessment was carried out after 21 days in which the cosmetic containing L. acidophilus PBS067 under examination was judged positively by the majority of parents on all the aspects investigated in Figure 6.
Conclusion Based on the reported tests and scientific research conducted by Roelmi HPC on sensitive and newborn skin, EquiBiotics LA appears to be an ideal partner for rebalancing skin dysbiosis in sensitive adult skin, reducing TNF-α expression by 32.6% after just 24 hours and improving the integrity of the epithelial barrier (TEWL). Clinical trials on 22 children between three and 36 months have also demonstrated the ability of the biotech ingredient to reduce infantile erythema with a p-value <0.001 after just seven days. A very positive parent assessment analysis after 21 days of treatment shows an overall improvement in patients’ skin conditions. In conclusion, the ingredient stands out to be
an effective, safe postbiotic, easy to incorporate into the water phase and suitable for all sensitive skin from three months of age.
References 1. Cogen AL et al. Skin microbiota: a source of disease or defence? Br. J. Dermatol. 2008; 158:442–455
2. Probst AJ et al. Moissl-Eichinger C. Archaea on human skin. PLoS One. 2013; 12 June
3. Fuchs E et al. Getting under the skin of epidermal morphogenesis. Nature Rev. Genet. 2002; 3:199–209
4. Cundell AM. Microbial Ecology of the Human Skin. Microb. Ecol. 2018; 76:113–120
5. Farahmand S. Microbiome of Compromised Skin. In: Skin Microbiome Handbook: From Basic Research to Product Development. 1st ed. Scrivener Publishing LLC; Beverly, MA, USA: 2020; pp. 145–170
6. Maibach HI. The cosmetic intolerance syndrome. Ear Nose Throat J. 1987; 66:29–33
7. Farage MA, Katsarou A, Maibach HI. Sensory, clinical and physiological factors in sensitive skin: a review. Contact Dermatitis. 2006; 55:1–14
8. Willis CM, Shaw S, De Lacharriere O et al. Sensitive skin an epidemiological study. Br J
100 80 60 40 20 0
PCM Skin erythema
3 2 1
0 T0 T3
Figure 4: Skin eryhtema reduction: clinical study on 22 on infants/children T0
T3 T7 ** ***
T7
Figure 5: Photographic evaluation on 22 infants/children Dermatol. 2001; 145:258–263
9. Misery L, Boussetta S, Nocera T et al. Sensitive skin in Europe. J Eur Acad Dermatol Venereol. 2009; 23:376–381
10. Jourdain R, de Lacharriere O, Bastien P, Maibach HI. Ethnic variations in self-perceived
sensitive skin: epidemiological survey. Contact Dermatitis. 2002; 46:162–169
11. Seidenari S, Francomano M, Mantovani L. Baseline biophysical parameters in subjects with sensitive skin. Contact Dermatitis. 1998; 38:311–315
Subject who did not show an improvement ■ Subject who showed an improvement ■
Protective film on skin
Nourished skin
Softer skin
Reduced redness
Figure 6: Parental questionnaire assessment on 22 infants/children PERSONAL CARE MAGAZINE March 2026
www.personalcaremagazine.com
Prevent the apparition of the irritation
Reduced sensation of irritation
Prevent the apparition of the redness
Soothed skin
resistant skin
More
(%) of subject
TEWLScore scale (0-4)
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