84 SKIN MICROBIOME M. furfur
M. globosa M. restricta
C. kroppenstedtii
C. tuberculostearicum S. capitis S. aureus
S. epidermidis C. granulosum C. acnes
-4 -3 Impact score (Log) -2 -1 0 1 -4 -3 Impact score (Log) -2 M. furfur
M. globosa M. restricta
C. kroppenstedtii
C. tuberculostearicum S. capitis S. aureus
S. epidermidis C. granulosum C. acnes
-1 0 1 -3 -2 Impact score (Log) M. furfur
M. globosa M. restricta
C. kroppenstedtii C. tuberculostearicum
S. capitis S. aureus
S. epidermidis C. granulosum C. acnes
-1 0 1
M. furfur
M. globosa M. restricta
C. kroppenstedtii
C. tuberculostearicum S. capitis S. aureus
S. epidermidis C. granulosum C. acnes
-3 Impact score (Log) -2 -1 0 1 -4 -3 Impact score (Log) Figure 2: Data obtained from in vitro tests performed in the microbiology laboratory at Byome Labs
of S. epidermidis may be strategic, since its sphingomyelinase promotes ceramide production and strengthens barrier function. This activity also favours stable colonization of S. epidermidis in its niche, contributing to community stability.8,9 ■ pH and control of opportunists: Cutibacterium acnes hydrolyses sebaceous lipids into free fatty acids, including propionic acid, which lowers surface pH and creates an environment unfavourable to the growth of pathogens such as Staphylococcus aureus.8–10 Local immunomodulation and tight junctions: commensals such as S. epidermidis can stimulate TLR2 on keratinocytes, increasing endogenous AMP production and strengthening the tight junction barrier, thereby preserving homeostasis.12 In practice, this argues for microbiome
compatible care that supports these natural functions through a managed acidic pH, appropriate lipid supply, antioxidants, and pre-, pro-, and postbiotics.
Conclusion Figure 2 shows results from in vitro tests performed in the microbiology laboratory of Byome Labs. It displays impact profiles, expressed as log10 variation, for several formulas on a panel of microorganisms representative of the skin microbiome. At Byome Labs, strains are selected from NGS sequencing data and the literature in order to refine our models, for example mature skin and dry, oily, or moist sites. Here, each product exhibits a distinct signature, which underscores the importance of measuring the effect of every formula on the microbiome to guide formulation and to objectively substantiate microbiome compatibility. At Byome Labs, we are committed to
understanding microbiomes to improve consumer health. Our ambition is to establish new standards in microbiome testing and product recommendations in order to reduce waste, strengthen the efficacy of care, and
PERSONAL CARE November 2025
accelerate the transition toward transparent, microbiome respectful beauty. To achieve this, we draw on more than 20
years of expertise in microbiology, with strong competencies in biofilm biology, immunology, genetic engineering, and artificial intelligence. We already apply these capabilities through customized services tailored to the specificities of our clients’ products and needs, whether the focus is the skin, vaginal, oral, or scalp microbiome, and including issues such as dysbiosis or the scientific demonstration of microbiome compatibility. Our expertise in in vitro microbiome testing
has been concentrated into Byome Derma™, our instant skin microbiome test coupled with an artificial intelligence system designed with dermatologists, which recommends products adapted to each consumer’s microbiome.
3. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-70
4. Howard B, Bascom CC, Hu P, Binder RL, Fadayel G, Huggins TG et al. Aging-Associated Changes in the Adult Human Skin Microbiome and the Host Factors that Affect Skin Microbiome Composition. J Invest Dermatol. 2022;142(7):1934-1946.e21
5. Boxberger M, Cenizo V, Cassir N, La Scola B. Challenges in exploring and manipulating the human skin microbiome. Microbiome. 2021;9(1):125
PC
References 1. Lee H, Hong Y, Kim M. Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin. Int J Mol Sci. 2021;22(22):12489
2. Woo YR, Kim HS. Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review. Front Physiol. 2024;15:1322205.
6. Xia J, Hochgerner M, Wei Q, Zhong X, Wang J. Redefining the Skin Barrier: A Microbiome- Integrated Multilayered Defense Model. Barrier Immun [Internet]. 24 July 2025. https://
onlinelibrary.wiley.com/doi/abs/10.1002/ dni2.70002
7. Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017;9(378):eaah4680
8. Zheng Y, Hunt RL, Villaruz AE, Fisher EL, Liu R, Liu Q et al. Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides. Cell Host Microbe. 2022;30(3):301-313.e9
9. Fournière M, Latire T, Souak D, Feuilloley MGJ, Bedoux G. Staphylococcus epidermidis and Cutibacterium acnes: Two Major Sentinels of Skin Microbiota and the Influence of Cosmetics. Microorganisms. 2020;8(11):1752
10. Ito Y, Amagai M. Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases. Inflamm Regen. 2022;42(1):26
11. Luna PC. Skin Microbiome as Years Go By. Am J Clin Dermatol. 2020;21(Suppl 1):12-7
12. Shibagaki N, Suda W, Clavaud C, Bastien P, Takayasu L, Iioka E et al. Aging-related changes in the diversity of women’s skin microbiomes associated with oral bacteria. Sci Rep. 2017;7(1):10567
www.personalcaremagazine.com -2
M. furfur
M. globosa M. restricta
C. kroppenstedtii
C. tuberculostearicum S. capitis S. aureus
S. epidermidis C. granulosum C. acnes
-1 0 1
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107
