52 LONGEVITY
Beyond lifespan: exploring the science of longevity
Audrey Le Mestr, Eloïse Collet – Ashland
Over the past few decades, medical advances have significantly increased human life expectancy. However, extending lifespan alone is not enough. The important goal that we all share is to increase health span, defined as the period of life spent in good health, with full capacity and vitality, without chronic disease or functional decline. These new expectations have redefined the
goals in terms of supporting ageing and opened the door to the modern concept of longevity. Longevity is a constructive approach that views ageing not as an inevitable decline, but as a biological process that can be modulated. At the core of this shift lies a new scientific
field called geroscience, that investigates the molecular and cellular mechanisms leading to ageing. Geroscience stems from the principle that ageing is nothing more than a biological program that can be analysed, modulated, and potentially reversed. Additionally, ageing is now recognized as a systemic and multifactorial process, driven by complex interactions between several biological pathways. This new perspective has been greatly
supported by the integration of artificial intelligence (AI), which enables large-scale data analysis and accelerates the development of personalized strategies for longevity. AI- driven tools, for example, are increasingly used in diagnostics and in the design of tailored regimens that combine skincare, nutraceuticals, electronic devices, and lifestyle adjustments.
Longevity science and the 12 hallmarks of ageing López-Otín and his research team brought a major conceptual advance in this field, with the identification of the hallmarks of ageing.1
numbered as nine, and now expanded to 12, these hallmarks represent the key biological mechanisms that drive the ageing process from the earliest stages of life. Each hallmark fulfils three essential criteria:
(1) it correlates with chronological age; (2) its exacerbation accelerates the ageing process; and (3) its modulation can delay, and in some cases, even reverse some aspects of ageing. They can be divided into three categories:
(1) the primary hallmarks, considered as the root causes of ageing; (2) the antagonistic hallmarks, which represent how our organism responds and adapts to damage; (3) the integrative hallmarks, which are the downstream consequences of damage. Importantly, these
PERSONAL CARE November 2025
hallmarks are not independent; they are interconnected and collectively contribute to the progressive functional decline of cells, tissues, and organs. These hallmarks have been recognized and
Initially
acclaimed by the entire scientific community and have had a considerable impact in the field of longevity science. Who can still ignore them today? First, they provide robust guidelines for identifying biological targets for innovation. Second, they reinforce the notion that effective interventions against ageing are possible. Finally, they support a shift from a corrective
approach of ageing, focused only on the visible signs, to a preventive and regenerative strategy, aimed at preserving and even enhancing cellular and tissue functionality over time.
Pioneering longevity science for over 20 years The science of longevity is in Ashland’s DNA. Thanks to decades of research in the field of skin biology, even before the first edition of this bible of hallmarks of ageing was drafted,
Ashland solvers have genuinely explored some of these biological pathways, translating complex biological insights into innovative bioactive solutions that support skin resilience and beauty through ageing. Over time, our offering has expanded into a
complete range of cosmetic biofunctionals with targeted actions and robust scientific validation that act on mitochondrial vitality, epigenetic mechanisms, cellular energy, and more, culminating in the creation of a cutting-edge platform dedicated to skin longevity. In this article, we focus on five bioactive
examples, each providing a unique solution to target the hallmarks of ageing and illustrating Ashland’s expertise in the field of skin longevity.
A rose extract rich in plant small RNAs Rosaliss™ biofunctional is a 100% natural extract of Rosa centifolia’s flowers obtained with Ashland Plant Small RNA™ technology (PSR™), which is an innovative, proprietary and patented chemical process, that was designed
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