54 LONGEVITY
by the circadian clock, whose expression peaks at the beginning of the night. Nocturnin is considered as a moonlighting protein with a dual function. This protein acts as an endonuclease and is part of the quality regulation of aberrant mRNA transcripts, by degrading poly-adenosine tails.7 On the other hand, nocturnin ensures
bio-energetic functions and regulates cell metabolism.8
Application of 0.1% Lavendula
angustifolia flower extract on keratinocytes was associated with an increase in nocturnin’s expression, demonstrating its ability to help fight against epigenetic alterations (Figure 5).
A marine extract from giant kelp algae Derived from giant kelp - Macrocystis pyrifera, a brown algae with exceptional growth and regeneration potential that thrives on the Pacific coast of the United States, Seastem™ biofunctional has been designed to preserve the skin stemness potential and improve its self-regenerating and protecting properties against pollution. To fully harness the biological power of
this brown algae, this unique Macrocystis pyrifera extract is obtained using Ashland Zeta Fraction™ technology, a patented and proprietary solvent-free process, which directly transforms the fresh plant to reveal its full potential. In this study, we evaluated the effect of
Macrocystis pyrifera extract on stem cell exhaustion, a loss capacity of tissue renewal and repair linked with ageing. For that purpose, SOX9 was studied in a pollution-model of ultra fine particles (UFPs) from diesel car exhaust. SOX9 is an important stem cell regulator that helps maintain the cellular niche microenvironment. It is also an important early marker that indicates the skin’s stemness
Figure 3: claudin-1 expression on dysbiosis-RHE model treated with Rosa centifolia extract ***: highly significant with Student t-test, n=3
potential.9 UFP-exposed keratinocytes showed a
decrease of SOX9 expression compared to unstressed condition. Following the application of 0.01% Macrocystis pyrifera extract, UFP- exposed keratinocytes showed a lower decrease of SOX9, compared to the UFP stressed (Figure 6). The potential of this Zeta Fraction giant
kelp extract to act on stem cell exhaustion has also been highlighted by evaluating stem cell proliferative capacity and stem cell niche, regarding keratin 15 and p63 markers respectively (data not shown).
A sandalwood extract inspired by forest therapy Inspired by scientific research on the benefits of forest therapy, showing that certain volatile organic compounds can stimulate the olfactory pathway and provide very interesting benefits, such as anti-inflammatory effects,10
Asland
developed an innovative extract of Santalum album obtained by supercritical CO2
Due to its unique composition, consisting
of a volatile fraction and a lipid fraction, Santalwood™ biofunctional can act on the skin’s olfactory receptors, a class of sensory
4 hours after irradiation extraction.
receptors recently described in the skin, alongside visual receptors, demonstrating the extent to which the skin is an organ endowed with ‘senses’. By targeting the skin’s olfactory receptor
OR2AT4, expressed by epidermal keratinocytes, melanocytes, dendritic cells, and hair follicles, this unique Santalum album wood extract offers an original approach to well ageing, senescence & skin barrier regeneration. OR2AT4 activation increases the proliferation and migration of keratinocytes, allowing faster re- epithelialization during wound healing.11 The senolytic property of this Santalum
album wood extract was investigated on senescent fibroblasts (Figure 7). Cell viability of P12 cells incubated with
increasing concentration of the bioactive compound was unchanged. However, a significant decrease in cellular viability of senescent P37 fibroblasts was observed with increasing concentration of the extract, suggesting that our Santalum album wood extract selectively favours the elimination of senescent cell population, indicating a senolytic-like activity. This Santalum album wood extract can also target the ‘deregulated nutrient sensing’
24 hours after irradiation
Figure 4: CPDs immunofluorescent detection in melanocytes irradiated with UVB and treated with Lavendula angustifolia flower extract. ***: highly significant with Student t-test versus proper control, n=3. ***: highly significant with Student t-test, n=3
PERSONAL CARE November 2025
Figure 5: Nocturnin immunofluorescent detection in keratinocytes treated with Lavendula angustifolia flower extract. ***: highly significant with Student t-test, n=3
www.personalcaremagazine.com
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