SKIN INFLAMMAGING
cognitive decline, and frailty, while TNF-α contributes to muscle wasting and insulin resistance. Conversely, maintaining a balanced pro-
and anti-inflammatory cytokine profile is associated with successful aging, characterized by preserved immune competence and lower incidence of chronic disease. Therapeutic strategies under investigation include targeted cytokine inhibition (anti-IL-6 antibodies, TNF blockers), modulation of inflammasome activity, and lifestyle interventions such as caloric restriction and exercise, which have been shown to normalize cytokine levels.
The threefold mode of action of Ectoin natural against skin inflammaging Ectoin natural is a stress-protective cyclic amino acid, valued for its capacity to safeguard cellular structures and essential biomolecules against internal and external stress. Its anti- inflammaging potential is achieved through a multifaceted, three-phase mechanism that intervenes at the onset, persistence, and resolution of skin inflammation.
1. Prevention of inflammation: cellular protection and membrane stabilization Ectoin natural acts as a molecular shield, forming a protective water shell around cellular structures through its unique compatible solute mechanism. This hydration shell stabilizes cell membranes, lipids, and proteins, thereby: ■ Preventing structural damage caused by environmental stressors such as UV radiation, pollution, and oxidative agents. ■ Reducing reactive oxygen species (ROS) generation at the mitochondrial and cellular level, thereby lowering oxidative stress—a key trigger of inflammaging. ■ Limiting the initial activation of pattern recognition receptors (PRRs) and subsequent NF-κB pathway stimulation, which prevents the transcription of pro-inflammatory mediators.
2. Treatment of existing inflammation: cytokine and pathway modulation Ectoin exerts a potent immunomodulatory effect, attenuating the inflammatory cascade by: ■ Downregulating pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, which are hallmarks of the inflammaging cytokine signature. ■ Inhibiting NF-κB signaling, the central transcriptional regulator driving chronic inflammation and tissue degradation. ■ Reducing oxidative mediators such as nitric oxide (NO) and prostaglandins, leading to decreased erythema, oedema, and inflammatory cell infiltration. ■ These combined effects interrupt the vicious cycle of chronic inflammation, mitigating tissue damage and slowing the progression of inflammaging.
3. Promotion of repair: barrier restoration, hydration and skin regeneration Beyond anti-inflammatory effects, Ectoin enhances skin barrier integrity and supports regenerative processes by:
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■ Stimulating the synthesis of key barrier lipids (ceramides) and structural proteins (filaggrin), leading to improved barrier function. ■ Decreasing transepidermal water loss (TEWL) and enhancing skin hydration, crucial for maintaining epidermal homeostasis. ■ Supporting cellular regeneration and matrix remodelling, thereby reducing visible signs of ageing such as roughness and fine lines. Clinical studies show that topical Ectoin
significantly reduces erythema, roughness, and transepidermal water loss. Its dual action—anti- inflammatory and barrier-protective—makes Ectoin a highly effective bioactive for combating age-related inflammation and maintaining skin health in cosmetic and dermatological applications.
Clinical evidence Long-term skin barrier repair and anti- inflammatory efficacy (in vivo) In a double-blind, randomized, placebo- controlled clinical study the test products were
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a cream containing 1% Ectoin natural, control (0.25% Hydrocortisone) ‘Ebenol Cream’, placebo cream One percent Ectoin natural reduced the TEWL
by 24% and skin redness by 38% after only seven days of treatment, due to its anti-inflammatory and repairing properties. The efficacy of 1% Ectoin natural was equivalent or even better than the results of the treatment with Ebenol, proving its ‘hydrocortisone-like’ efficacy. Furthermore, a recent in vivo clinical study
also proved the short-term anti-inflammatory efficacy of Ectoin natural. 2. Short-term skin barrier repair and anti- inflammatory efficacy (in vivo) Single application of 0.5% Ectoin natural is clinically proven to strengthen the skin barrier within four hours, with a reduction of TEWL and skin irritation by 60%. 0.5% Ectoin natural also demonstrates long-
term skin barrier and skin-soothing efficacy up to 48 hours (single application) with a reduction of TEWL by 72%.
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November 2025 PERSONAL CARE
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