LONGEVITY
studies show that senescent cells can be induced by senolytic molecules to undergo apoptosis, leaving tissues free to regenerate and return to a healthier state.7,8 Scientists at DSM-Firmenich are experts in the understanding of the behaviour of senescent cells, and in ways they can be removed from skin. Through systematic screening for natural senolytic and senomorphic compounds, they have developed a powerful fully sustainable natural senolytic from the rare alpine plant Epilobium fleischeri, Eterwell™ Youth.
This innovation triggers programmed cell death in senescent cells by reducing levels of BCL-2, a protein that normally prevents apoptosis. This allows senescent cells to die and be removed through natural processes. Their pioneering studies demonstrate that cellular-level interventions can reduce populations of senescent cells, rejuvenate tissue, and improve appearance.
Senolytics: transforming the skin’s response to anti-ageing actives Intuitively, scientists at DSM-Firmenich hypothesized that, once senolytics, like Eterwell Youth, had cleared away senescent cells, they would create a new ‘’fresh tissue landscape’’ where traditional cosmetic actives such as collagen-boosters, could be even more effective. Research has now validated this approach,
showing that senolytic science can significantly enhance the efficacy of established cosmetic ingredients. This synergy represents the future direction of skin care, when actives that remove barriers to renewal will be combined with traditional ingredients that address the hallmarks of ageing. The resulting boosted efficacy will set new standards for maintaining healthy, vibrant skin throughout life. This ingenious idea of pairing senolytic with traditional skin care actives to enhance their
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Age 47
Age 54
Age 61
1.5% Palmitoyl Tripeptide-5 ■ 1.5% Palmitoyl Tripeptide-5 + 1% Eterwell™ Youth ■ PORES NUMBER CHANGES
0 -5
-10 -15
-20 -25
0 -5
-10 -15
-20 -25 30
-8% * -16% ** -27% 4 weeks Figure 3: Interconnected hallmarks of ageing
effectiveness was successfully demonstrated using DSM-Firmenich's collagen booster SYN®-COLL CB (Palmitoyl Tripeptide-5), in a two-month, single-blind, randomized, half-face clinical study with 55 Chinese volunteers aged 45-65.
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Each volunteer had one side of their face
treated with a test product formulated with either 1.5% Palmitoyl Tripeptide-5 alone or with 1.5% Palmitoyl Tripeptide-5 combined with 1% Eterwell Youth. While Palmitoyl Tripeptide-5 alone significantly improved collagen density
8 weeks -13% -7% * -14% 4 weeks 8 weeks PORES VOLUME CHANGES -10% * -20%
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sales@asdsoftware.com November 2025 PERSONAL CARE
Pores volume reduction vs control (%)
Pores number reduction vs control (%)
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