52 ANTI-AGEING
asked to provide feedback on the efficacy of the tested product by completing a self- questionnaire. Based on their responses, the triple efficacy of the endophytic ferment was clearly highlighted.
Conclusion In alignment with its core values, Provital introduces Pureblome, an innovative post-biotic ingredient developed through Triplobiome technology. Embodying the harmony of a natural ecosystem, it provides a comprehensive skin balance through the interkingdom symbiosis created between the endophytic bacterium Bacillus velezensis, and its host plant, the hyssop. Sourced from the interior of the leaves of
this antimicrobial plant, this unique fermented ingredient offers a multifaceted solution to the current challenges faced by mature women. Supported by rigorous in vitro and in vivo
research, Pureblome addresses the unique needs of adult women with a triple-efficacy approach, blending anti-acne and well-being benefits. First, it promotes skin regeneration by
improving epidermal turnover, together with enhancing fibroblast migration, collagen and elastin production, and a better elasticity, supporting well-ageing. Second, by reducing sebum, it visibly
shrinks pores, diminishes microbial markers, and mattifies the skin. Third and final, its anti-‘inflammaging’ action balances acne- prone, ageing skin by reducing cytokines and improving skin tone, restoring harmony and radiance. A metabolomic analysis and a peptide
standardization ensure the transfer of the metabolic intelligence generated within the symbiotic relationship between hyssop and the endophytic bacterium to the skin. In essence, Pureblome adopts an agro-
psychology approach—cultivating balance and well-being in harmony with nature. This holistic, eco-responsible ingredient empowers women to thrive in beauty and confidence, delivering nature’s regenerative power directly to the skin.
References 1. Kumari P, Deepa N, Trivedi PK, Singh BK, Srivastava V, Singh A. Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites. Microbial Cell Factories. 2023; Vol. 22
2. Valenzuela-Aragon B, Parra-Cota FI, Santoyo G, Arellano-Wattenbarger GL, de los Santos-Villalobos S. Plant-assisted selection: a promising alternative for in vivo identification of wheat (Triticum turgidum L. subsp. Durum) growth promoting bacteria. Plant Soil. 2019 Feb 7;435(1–2):367–84
3. Fathiazad F. A review on Hyssopus officinalis L.: Composition and biological activities. African Journal of Microbiology Research. 2011; 5(17)
4. Ichihashi M et al. Glycation Stress and Photo-Aging in Skin. Anti-Aging Medical
PERSONAL CARE May 2025 T0 T56 T0 T56
forehead T0
T56
nose T0
T56
cheek T0
T56
T-0
T56
chin
Figure 4: Clinical Expert Improvement Analysis of Volunteer no 65’s Skin under UV Light. Protoporphyrin IX’s (red dots) Evolution on Day 0 vs. Day 56 of Treatment with 2% of the Studied Endophyte Active Ferment
T-0 T56
Figure 5: Post-inflammatory regeneration and reduction of acne spots. Cross-Polarized Images of Volunteer no.12 on Day 0 vs. Day 56 of Treatment with 2% of the studied Endophyte Active Ferment
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Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University. 2011
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6. Dipietro LA, Burns AL, Reed MJ, Koike T, Puolakkainen P. Wound Repair in Aging Wound Repair in Aging A Review. Methods Mol Med. 2003:78:217-37
7. Chowdhury SR, Jing LS, Zolkafli MNH Bin, Zarin NABMA, Abdullah WABW, Md Mothar NAB et al. Exploring the potential of dermal fibroblast conditioned medium on skin wound healing and anti-ageing. Sains Malays. 2019; Mar 1;48(3):637–44
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