ANTI-AGEING
51
T-0
Average Pore Size variation in volunteers vs Placebo
Average Blemish number variation in volunteers vs Placebo
*p<0.05; **p<0.01; ****p<0.001
Figure 3: Profilometric Measurement with Primos-CR in Pore & Blemish Refining Evolution of Volunteer nº 68 on Day 0 vs. Day 14, 28 and 56 of Treatment with 2% of the Studied Endophyte Active Ferment
with more than 50% of the subjects reporting a noticeable change. After 56 days, a significant 75%** of volunteers improved in matte appearance. Additionally, the amount and distribution
of protoporphyrin-IX, a metabolic byproduct of C. acnes,13
suggested a reduction in
the bacterial population across the skin, underscoring the significant antimicrobial activity of the active ingredient. After 56 days, a substantial 89%** of volunteers were quantified to show a decrease in protoporphyrin-IX, in vivo (Figure 4).
All-encompassing anti-inflammatory action to reach total evenness Finally, an all-encompassing anti- inflammatory action serves as a unifying factor, reducing cytokine activity and promoting an
even skin tone, while restoring the balance disrupted by ‘inflammaging’.
Inflammatory response reduction IL-6 and IL-8 are key cytokines in acne research, as they are secreted by sebocytes in response to C. acnes.14
The inflammatory
processes in response are also linked to premature ageing, a phenomenon known as ‘inflammaging’.15 Sebocytes were treated with 0.056% of the
endophytic ferment, after lipid production and cytokine secretion were induced. The levels of both cytokines were then quantified in the supernatants, revealing a significant reduction of 33.5%* in IL-6 and 41.4%** in IL-8.
Post-inflammatory relief & regeneration Thanks to a clinical study conducted on
a younger panel (30-40 years old), the visible disappearance of acne spots, reduction in blemishes, post-inflammatory hyperpigmentation (PIH), and acne marks across the skin were assessed. As a result, a significant 78%*** of
volunteers clinically improved in skin regeneration (Figure 5) after 56 days of treatment with the endophytic ferment.
General skin tone & youthful appearance This endophytic ferment reveals its well- ageing and balancing properties when reversing the uneven skin tone colour on volunteers by -9.3%*** compared to placebo in vivo, and a 86%**** of volunteers showed a clinically relevant improvement in the balance of the overall skin tone; both after 56 days. After the clinical study, all volunteers were
T14 -5.2%**** vs Placebo
-7.8%* vs Placebo
T28 -7.2%****vs Placebo
-10.6%** vs Placebo
T56 -10.1%****vs Placebo
-10.7%* vs Placebo
www.personalcaremagazine.com
May 2025 PERSONAL CARE
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