SKIN CARE
Redness Self-Assessment - Parameters of Inflammation
Inflammation & Skin Reactivity 4 * 3 * 2 1.9 1.5 1 0 0.4 1 0 0.4 1.5 1 0 0.4 2.2 2 1.9 * 3 * 2.2 2 1.6 1.7 * 4 * 3 * 2.3 *
31
Discomfort (Burning, Stinging, Pain) 4
*
Figure 7: The moringa seed extract improves skin redness, inflammation, and discomfort. In a double-blind placebo-controlled clinical study, volunteers’ skin was irritated using a dermaroller and then either left untreated or treated with creams containing: 0% the moringa seed extract + 0% SLM (placebo), 2% moringa seed extract, or 2% moringa seed extract + 20% SLM. At the end of the treatment, participants ranked improvements in skin redness, inflammation and reactivity, and discomfort using a scale: best treatment (3 points), second best treatment (2 points), third best treatment (1 point), worst treatment (0 points). Results are shown as average scores. Data is presented as mean + SEM. Statistical analysis was performed using the Wilcoxon test to compare treated versus untreated areas. * = p < 0.05. N = 15
of 0.3 mm. The device was applied to four randomized areas on the forearm, which induced increased blood flow and barrier irritation, as evidenced by elevated microcirculation and transepidermal water loss (TEWL) (Figure 6). After this initial damage, a repair phase
began, during which each area was treated with either a test cream, a placebo cream, or left untreated. The time for complete recovery of microcirculation was monitored via the Periflux PF5000 and the time for complete recovery of the skin barrier (TEWL) was measured with a Tewameter® TM 300. Photographs were captured using
IntelliStudio®. In addition, participants completed a questionnaire after the first application and after complete recovery to share their experience with the product and opinion about possible applications for the moringa seed extract.
91% Agreement
100% Agreement
91% Agreement
Self-assessment – parameters of inflammation As a result, instrumental analysis revealed that the time needed for complete recovery of dermaroller-treated skin is significantly shortened by the moringa seed extract alone, and even more in combination with Skin Lipid Matrix SLM. Microcirculation normalized 47% faster with a 2% moringa seed extract treatment alone and 51% faster when combined with SLM, as compared to untreated skin. In parallel, TEWL reached normal levels 30% faster with the the moringa seed extract and 55% faster in combination with SLM, relative to the control (Figure 6). Furthermore, the people who tested the
treatments rated the 2% moringa seed extract + SLM combination as the best, followed by 2% moringa seed extract alone. Thus, combining the moringa seed extract with SLM works even
73% Agreement 73% Agreement 73% Agreement
better for skin recovery and protection (Figure 7). Participants also said that the moringa seed extract would also be effective in soothing shaved skin, reducing bruising, and caring for tattoos or piercings, highlighting its broad potential for cosmetic applications (Figure 8).
Conclusion The moringa seed extract is an effective, ethical, and eco-friendly active ingredient. Derived from upcycled moringa seed cake (Moringa oleifera) of traceable origin, this preservative-free, self- preserving glycerinic-aqueous extract combines traditional African knowledge with modern cosmetic science. It significantly accelerates the recovery of irritated skin, especially in combination with Skin Lipid Matrix® SLM, making it a great choice for skin recovery and protection.
References 1. Pareek A et al. Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. Int J Mol Sci. 2023; 24 (2098), 1-36
2. Leone A et al. Moringa oleifera seeds and oil: characteristics and uses for human health. Int J Mol Sci. 2016; 17 (2141), 1-14
Microneedling
Needle patches
Shaving lesions
Bruises Tattoos Piercings
Figure 8: The moringa seed extract is regarded by consumers as a suitable and effective ingredient for various cosmetic applications. After having used the moringa seed extract test cream, users expressed their opinion about its suitability for various applications by responding to the question: ‘Do you think this cream is effective for the following applications?’ with the options: ‘Yes, definitely’, ‘Rather yes’, ‘Rather no’, and ‘No, not at all’. Results are presented as the percentage of positive responses (Yes, definitely’ and ‘Rather yes’). N=15
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3. Apaza L et al. Moringa oleifera Lam. leaf extract: anti-inflammatory and antioxidant cosmetic ingredient for holistic skin and hair. SOFW Journal. 2020; 146 (3), 26-33
4. Zahirah N et al. Moringa genus: a review of phytochemistry and pharmacology. Pharmacology. 2018; 9 (108), 1-26
5. Gugliandolo Aet al. α-Cyclodextrin/ moringin induces an antioxidant transcriptional response activating Nrf2 in differentiated NSC-34 motor neurons. Antioxidants. 2024; 13 (813), 1-16
May 2025 PERSONAL CARE
PC
Consumer Rating
Untreated Placebo
2% Moringa Seed Extract
2% Moringa
Seed Extract + SLM
Untreated Placebo
2% Moringa Seed Extract
2% Moringa
Seed Extract + SLM
Untreated Placebo
2% Moringa Seed Extract
2% Moringa
Seed Extract + SLM
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