SUN CARE 41
Table 1: Examples of Clinical Trials Performed on Products that Blend in Our Fullerene Raw Materials for Cosmetics. Item
Subject Skin Whitening 18 Women Application Method
2 times, morning and evening, applied to entire face (0.4 ml), fullerene- blended cosmetic lotion.
Anti-Wrinkle 23 Women
2 times, morning and evening, fullerene-containing cream or placebo cream applied to a specified half of the face (0.3 g).
Prevention of Pimples
Pore Improvement
5 Men 6 Women
2 times, morning and evening, applied to entire face (0.4 ml),
fullerene-blended gel. 10 Women
Rough Skin Improvement
5 Men 5 Women
2 times, morning and evening, applied to entire face, fullerene-blended lotion. 2 Months
2 times, morning and evening,
applied 0.1 g to indicated locations on the inside of the forearm using a cotton swab.
Suppression of Sebum Oxidation
3 Men 8 Women
Foundation blended or not blended with fullerenes, applied to a specified half of the face (40 mg).
4 Days Time 8 Weeks Evaluation Method
Measurement of the melanin index of the cheek using a spectroscopic colorimeter.
8 Weeks
Analysis of items such as the wrinkle area ratio using replica two- dimensional analysis.
8 Weeks
Measurement of the number of pimples using doctor findings,
photographic images, etc.
Measurement of pore score using VISIA.
Measurement of the TEWL of rough skin sites using a tape strip, and calculation of the barrier recovery ratio.
6 Hours
Collection and extraction of sebum, and measurement of the amount of peroxidized sebum using a DPPP reagent.
Significant reduction in pore score after 2 months.
Compared with a control after 2-3 days, there was significant barrier function recovery and increase in mature stratum corneum cells.
The result of stratified analysis was that, in the group of subjects in their 30s, we verified a tendency for suppression of the formation of peroxidized sebum.
Results
Significant reduction in melanin index after 4 weeks and 8 weeks.
–
After 8 weeks there was a significant reduction in the wrinkle area ratio in the site where fullerene-containing cream was applied compared to the site where the placebo cream was applied.
Significant reduction in inflammatory rashes after 4 weeks.
4) Ref.
3)
5)
6)
–
face and hair. Table 1 shows some of the clinical trials that have been performed using our fullerene raw materials for cosmetics. The clinical trials were performed on subjects with problems such as spots and wrinkles,3 pimples,4
pore improvement,5 roughness improvement,6 and skin which were
considered to be caused by ROS. Lotions, creams, gels, and foundations that include 2 ppm of fullerene C60
were applied and
appropriately evaluated. In all the trials, the application of the fullerene-blended cosmetic product caused an improvement compared to the condition prior to cosmetic use.
Considering the mechanism by which
fullerene acts on the skin, it is believed that sebum oxidation as well as ROS, generated by ultraviolet rays, are reduced owing to the antioxidant effect of fullerene; therefore, skin problems such as spots and conspicuous pores diminish because of the anti-inflammatory effect. Problems such as wrinkles, pimples, and
rough skin are believed to worsen because of the presence of ROS as well as impairment of the skin’s barrier and moisturising functions. An increase in carbonylated protein reportedly contributes to skin problems such as dullness and dryness, and carbonylated
May 2019
protein also generates ROS, thereby promoting reactions that cause these problems. It has been experimentally verified that, when human stratum corneum, obtained by a tape strip, is irradiated with ultraviolet rays (UVA), the amount of carbonylated protein resulting from peroxylipids and protein is increased, and the addition of fullerene suppresses the increase in carbonylated protein (Fig 2). Therefore, an improvement in the moisturizing function as the result of
No UVA Irradiation UVA Irradiation
50 45 40 35 30 25 20
No additive p<0.01
decreased carbonylated protein is one reason for fullerene to be effective in protecting skin from problems such as wrinkles, pimples, and roughness. So far, from the results of clinical trials using fullerene-blended cosmetics, besides the elimination of ROS and the resistance to inflammation due to its antioxidant ability, it has been shown that fullerene improves the skin’s barrier and moisturizing functions, thereby toning the entire skin. Since it is believed that continuous skin problems are related to photoaging, for sun care, an effective approach is the daily use of cosmetics that include antioxidants such as fullerene.
1%RS RS: Radical Sponge
Figure 2: Suppression of the increase in carbonylated protein due to ultraviolet light by the use of fullerene (SCCP: stratum corneum carbonylated protein).
Fullerene raw material designed for sun care products The previous section discussed sun care with fullerene antioxidants; however, fullerene also has the ability to improve absorption of ultraviolet rays when it is combined with an ultraviolet ray absorber. This section discusses Sun Guard Fullerene A (fullerene-dispersed ethylhexyl methoxycinnamate), a fullerene raw material designed for sun care items that received an excellence award in the Effective Ingredients - Sun Care category of the 2018 Ringier Technology Innovation Awards.
PERSONAL CARE NORTH AMERICA
Carbonylation Level (SCCP Level)
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88
