ADAPTIVE SKIN CARE 77
In vivo 2 A second trial was conducted to further explore the active’s efficacy at a lower dose. Consistently with the results obtained in the
previous study (in vivo 1), the tolerogenic active statistically reduced skin redness in reactive skin up to 65.3% in 28 days (Figure 9). Across two independent clinical studies,
the active ingredient demonstrated consistent immune re-education of hyperreactive urban skin: measurable redness reduction, clinically confirmed erythema improvement, reduced functional signs of skin sensitivity, and directional reduction across key pro-inflammatory cytokines, confirming that the tolerogenic mechanism characterised in vitro translates to human skin under real-world conditions.
Conclusion This active is the first cosmetic tolerogen: a plant-derived recombinant human protein that re-educates hyperreactive urban skin to restore immune tolerance, comfort, and visible resilience. This biotech active ingredient operates
through a precisely defined and clinically validated mechanism: the tolerogenic reset of Langerhans cells.
This ingredient offers a new approach to
sensitive skin care: not simply calming the skin but helping it relearn how to stay calm. By combining immune re-education, tolerogenic signalling and barrier support, this breakthrough active enables formulators to move beyond traditional soothing concepts and develop advanced cosmetic solutions for hyperreactive, redness-prone and overstimulated urban skin. With a natural origin index of 99.99% (ISO
16128), China-compliant, microbiome compatible and Halal certified, this ingredient combines molecular precision with formulator accessibility and sustainability credentials. The active ingredient positions itself
at the forefront of a new generation of immunomodulatory cosmetic actives: those that do not merely calm the skin but teach it to tolerate.
Figure 9: Clinical photographs of a volunteer showing skin redness reduction (in vivo 2) PCM
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October 2026 PERSONAL CARE MAGAZINE Day 0 After 28 Days
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