PEPTIDES


30.0 25.0 20.0 15.0 10.0 5.0 0.0


71


Wrinkle and expression lines reduction - 28 days, 56 days and 84 days 28 Days ■ 56 Days ■ 84 Days ■ *


8.1 * N/S Placebo


Exosome Peptide Blend Facial Serum Products


Synthetic Peptide Benchmark


Figure 6: Both the exosome and natural peptide blend, and synthetic peptide benchmark showed a significantly greater decrease in wrinkles and expression lines at 28, 56 and 84 days as compared to the placebo


baseline control), with some reaching up to 26.0% improvement after 56 days and 24.6% (*p<0.05 versus baseline control), with some reaching up to 29.8% improvement after 84 days of study. The group using the formulation containing


the synthetic peptide benchmark showed a statistically significant reduction in the mean values of wrinkle intensity and expression lines of: 13.4% (*p<0.05 versus baseline control), reaching up to 19% after day 28, 19.0% (*p<0.05 versus baseline control), reaching up to 24.7% after day 56 and by 22.6% (*p<0.05 versus baseline control), reaching up to 28.8% after day 84.


The formulations containing both the


exosome and natural peptide blend, and the synthetic peptide benchmark showed significantly greater (+p < 0.05) improvements in wrinkles and expression lines than the placebo formula at all time points. However, no significant difference was observed between the formulas containing the exosome and natural peptide blend, and the synthetic peptide benchmark.


Conclusion Collectively, these findings indicate that the exosome and natural peptide blend technology is a high-performing, naturally derived approach to collagen banking and visible skin longevity. The combination of cutting edge, Centella asiatica stem cell-derived exosomes with well-established natural peptides extracted from Ganoderma lucidum delivers nature-inspired design with demonstrable performance. As clean beauty becomes a point of entry and


longevity becomes a key focus for skin care users, consumers will increasingly seek technologies that offer both high naturality and scientifically backed performance. The exosome and natural peptide blend, NeoColla, delivers cutting-edge scientific technology, proven performance, and the naturalness this consumer is looking for. This synergistic blend delivers statistically


significant improvements in dermal density, firmness, and wrinkle appearance that are comparable to a synthetic alternative, at a NOI of 0.99. With its outstanding natural origin profile and


statistically supported benefits, it is a strong option for longevity-seeking skin care enthusiasts.


References 1. Peptides Academy. (n.d.). History of peptides. https://peptidesacademy.co/learn/history


2. Chey WY, Chang TM. Secretin, 100 years later. J Gastroenterol. 2003;38(11):1025-35


3. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987


4. Harding CV, Heuser JE, Stahl PD. Exosomes: looking back three decades and into the future. J Cell Biol. 2013 Feb 18;200(4):367-71


5. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007 Jun;9(6):654-9


6. Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013 Feb;30(1):46-9


PCM 9.1 *


14.2 +


*


20.8 +


*


24.6 +


13.4 +


*


19.0 +


*


22.6 +


*


www.personalcaremagazine.com


October 2026 PERSONAL CARE MAGAZINE


Percent Change vs Baseline (%)

Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100  |  Page 101  |  Page 102  |  Page 103  |  Page 104  |  Page 105  |  Page 106  |  Page 107  |  Page 108  |  Page 109  |  Page 110  |  Page 111  |  Page 112  |  Page 113  |  Page 114  |  Page 115  |  Page 116  |  Page 117  |  Page 118  |  Page 119  |  Page 120  |  Page 121  |  Page 122  |  Page 123  |  Page 124  |  Page 125  |  Page 126  |  Page 127  |  Page 128  |  Page 129  |  Page 130  |  Page 131  |  Page 132