SCALP CARE 113 Notably, 100% of volunteers experienced
a reduction in flakes within seven days of treatment, regardless of scalp type (dry or oily), while the placebo produced no measurable effect. As noted above, dandruff is associated
with excess sebum production, which feeds the development ofMalassezia furfur. Sebum output was assessed using a Sebumeter® SM 815 and showed a significant, progressive reduction among volunteers using the shampoo formulated with 0.2% citrus peel oil ferment filtrate. By day 14, sebum production had decreased
significantly, by 25% to 56%; this reduction was maintained throughout treatment, reaching 48%, and increased further to between 52% and 92% at 14 days post-treatment (Figure 3). All volunteers using the active shampoo showed a reduction in sebum production, while the placebo shampoo produced no effect. The shampoo formulated with 0.2% citrus peel oil ferment filtrate also produced significant improvements in scalp epidermis integrity, soothing scalp sensitivity and signs of inflammation, with a marked reduction in scalp redness within seven days. Transepidermal water loss measurements
indicated that epidermal turnover was also normalised, supporting recovery of balanced epidermal maturation. The ferment filtrate reinforces the scalp’s epidermal barrier, which is frequently compromised in dandruff-prone scalps; a stronger barrier correlates with reduced irritation and improved resistance
Day 0 * p<0.0001
160 140 120 100 80 60 40 20 0
-24.7%* -47.6%* Measured sebum reduction ■ CitriVive ■ Placebo -51.9%*
D0
D14
D28 Figure 3: Effect of the citrus peel oil ferment on sebum production
to environmental stressors, and helps restore epidermal moisture, which is particularly beneficial for dry scalp. Self-assessment questionnaires corroborated these findings: 85% of the panel reported less dandruff within seven days, rising to 90% after 42 days, and 85% reported a less sensitive, less oily scalp over the same period. Furthermore, 90% of the panel considered that the shampoo containing the citrus peel oil ferment filtrate made their scalp healthier after only two washes, rising to 95% after 42 days — demonstrating both the immediate and long- lasting effect of the active ingredient.
Day 14
Conclusion There is high demand for efficient products to fight dandruff, yet most current solutions rely on antifungal synthetic chemicals. With CitriVive, Biosyntia offers a natural, multifunctional active ingredient with strong sustainability credentials. Its substantiated benefits are underpinned by a monoterpenoid-rich active fraction (>80% monoterpenoid content) naturally occurring in citrus species. This fraction is described in the literature
for multiple properties linked to protection and repair, which are particularly beneficial in recovering a healthy scalp. Used at 0.2% in a rinse-off shampoo, CitriVive
exerts an antifungal action by controlling the population ofMalassezia, reduces sebum production, and promotes epidermal repair by reducing signs of inflammation — leaving the scalp less red, less greasy and better hydrated. It provides rapid and long-lasting relief from excess flakiness and scalp discomfort, helping consumers recover their self-confidence.
Day 28 Day 42
References 1. Newton-Fenner A, Roberts H, Scott M, Jones T, Collins L, Godbehere A, Giesbrecht T. Clear scalp, clear mind: Examining the beneficial impact of dandruff reduction on physical, emotional and social wellbeing. Int J Cosmet Sci. 2025 Jun;47(3):466-475
2. Borda LJ, Wikramanayake TC. Seborrheic Dermatitis and Dandruff: A Comprehensive Review. J Clin Investig Dermatol. 2015 Dec;3(2):10.13188/2373-1044.1000019
3. Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. PLoS Pathog. 2012;8(6):e1002701
4. Turner GA, Hoptroff M, Harding CR. Stratum corneum dysfunction in dandruff. Int J Cosmet Sci. 2012 Aug;34(4):298-306
Figure 4: Images show fewer flakes and less sebum before and after 14 and 28 days of using a shampoo formulated with the citrus peel oil ferment filtrate, and 14 days after the last shampoo application
www.personalcaremagazine.com
5. Hardcastle IR, Rowlands MG, Barber AM, Grimshaw RM, Mohan MK, Nutley BP, Jarman M. Inhibition of protein prenylation by metabolites of limonene. Biochem Pharmacol. 1999 Apr 1;57(7):801-9
October 2026 PERSONAL CARE MAGAZINE
D28+14
PCM
Sebum quantity (µg/cm2
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