SKIN MICROBIOME 45
Biotech design of a postbiotic tackling skin dryness
Mélanie Coirier, Emilie Lasjaunias, Elodie Aymard, Brigitte Closs – Silab, France
Microbiota is currently a major research topic as well as a therapeutic target. Probiotics have long been qualified as ‘good bacteria’ whose administration in a suitable quantity provides health benefits. This theory now seems to be evolving, however, being replaced by the notion of postbiotics, a set of bioactive metabolites produced by probiotics.1
In the continuity of its initial work on the cutaneous microbiota, Silab became interested in these postbiotics and drew inspiration from the adaptation properties to desert climate of a probiotic of plant origin (Lactobacillus arizonensis). Based on its recognised expertise in mastering natural, microbiota and biotechnologies, Silab used a targeted bioguiding technology resulting from a biomimetic approach. It led to the selective production of bioactive molecules (postbiotics) that constitute Lactobiotyl®
, its novel active ingredient dedicated to dry skin.
A postbiotic bioinspired by desert climates
Selection of a probiotic strain of plant origin The prerequisite for the development of a postbiotic is to work from an identified probiotic strain. With its deep understanding of the plant kingdom, Silab selected a probiotic strain originating from a plant, belonging to the well-known family of
Abstract
Over the past 10 years, scientists have made enormous progress in the understanding of the role of the microbial flora on health. This progress has led to the emergence of new therapeutic strategies based on the use of probiotics (defined as good bacteria), and more recently of postbiotics, a set of bioactive metabolites produced by probiotics. Silab became interested in these beneficial effects and applied its expertise in mastering natural and biotechnologies to bioguide the production of a natural postbiotic capable of addressing dry skin issues, using a biomimetic approach.
lactobacilli. The company paid particular attention to Lactobacillus arizonensis, whose exceptional properties in the drastic environmental conditions of the Arizona desert directly inspired the company for the development of its latest active ingredient targeting dry skin.
Indeed, this bacterium is particularly known for its high adaptation capacity, being able to grow and survive in desert conditions. To do so, it can count on its remarkable genetic and metabolic characteristics, especially on its large genome, which can change in response to its environment. More precisely, Lactobacillus arizonensis colonises jojoba, one of the shrubs most adapted to desert climate and bioconverts jojoba’s molecular compounds in order to ensure its survival. It is therefore among the most adaptable bacteria since it can produce a very wide variety of active metabolites. These exceptional characteristics are the reason for its nickname of natural metabolic engineer.2
Production of a natural postbiotic by bioguiding
The company developed a controlled culture of the bacterium Lactobacillus arizonensis in industrial bioreactors in its on- site biotechnologies production unit. Since the capacity to produce postbiotics depends on the bacteria’s metabolism, it is of utmost importance to calibrate a basic parameter: the nature of nutrient supplies. In this case, the choice was made to follow a biomimetic approach by enriching the Lactobacillus arizonensis culture medium with an extract of jojoba, this strain’s original substrate, in order to reproduce its natural environment. This targeted bioguiding technology is an efficient way to obtain specific molecules of interest since it encourages the bacterium to produce the same bioactive molecules required for its survival in drought conditions (Fig 1). A metabolomics study by UPLC-MS/MS has identified these bioactive molecules.
Probiotic Lactobacillus arizonensis Figure 1: Production of bioactive metabolites by bioguiding. February 2020 PERSONAL CARE EUROPE
Jojoba extract
Postbiotic LACTOBIOTYL®
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