96 ANTI-AGEING Volunteer 1 Volunteer 2 SMOOTHING EFFECT


HETEROSIDES 0.2% reduces the number of microrelief furrows (depth <55um). D28: -36%*vs. Placebo for 87% of volunteers D56: -28%*vs. Placebo for 71% of volunteers


ANTI-WRINKLE EFFECT


HETEROSIDES 0.2% reduces the total wrinkled surface & the medium/deep wrinkles (depth <55um). D56: -19%*vs. Placebo for 71% of volunteers


Figure 2: Evaluation of relief quality - Placebo vs. Emulsion with 0.2% Heterosides 22 volunteers (age~59) with dry skin (HI<50) & with slight to moderate wrinkles on crow’s feet area. Twice-daily applications on hemi-face for 28 & 56 days - Skin Image Analyser®


+ Quantirides®


neutralises inflamm’aging, reinforces the skin’s architecture and improves the microvascular system. In only 14 days (Fig 3), Palmitoyl Glycine


restores a radiant and uniform complexion to the skin (+5% of parameter L* and -20% of parameter a*). In fact, tested in vitro, it reduced chronic inflammation by reducing IL-6 synthesis by 39%, it enhanced the formation of new vessels and tubular structure by 18% vs a control and it helped to protect and maintain the extracellular matrix (-56% MMP-1; +29% TIMP-2). Seppic includes this active in its “Fresh Complexion Youth Cream” (EU07143). Formulated at 1%, it visually reduces wrinkles in a month and a half (in vivo) and brightens the complexion in only 14 days (ex vivo). The mixed and enriched texture –


“Blooming Skin” Effect


without any fatty effect – of this formula is obtained thanks to the tremendous combination of Montanov™ 202 + Montanov 82 and brings comfort to the skin. The presence of Sepiplus™ 400 boosts the “silicone-like” effect of the cream. The skin is radiant, comfortable, soft with a matte finish.


Healthy ageing With ageing of the population, healthy living habits are becoming increasingly common, for present and future quality of life. The skin is no exception. According to a study conducted in the UK among 5,000 women, 62.4% think now that ‘anti- age’ consists of “preventing” the effects of skin ageing4 them.


rather than trying to correct software.


The response: Aqua / Water - Propanediol - Asparagopsis Armata Extract Aspar’AgeTM


(INCI: Aqua/Water - Propanediol -


Asparagopsis Armata Extract), the new wesource active, is an extract from the red seaweed Asparagopsis armata and protects the skin from endogenous stress using a unique approach: it controls contagious ageing (in vitro). In fact, ageing leads to an excess of senescent cells characterised by functional and morphological modifications. These cells also produce a ‘Senescence Messaging Secretome’, affecting neighbouring young cells and accelerating the signs of ageing. Tested in vivo (Fig 4) at 2% in the “Younger Look” Gel Cream formulation (EU07510), the active improves the perception of age in 28 days. Skin is perceived younger by people,


Radiant skin: greater luminosity (L✻ 5% (vs placebo)


)


Uniform complexion: less redness (a✻ -20% (vs placebo)


Figure 3: 14 days of treatment, topical application on skin explants , measurement of luminosity of the skin surface: L* , measurement of the reduction in redness on the skin surface: a*


PERSONAL CARE ASIA PACIFIC September 2019 )


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