76 LIFESTYLE COSMETICS 0 Days 7 Days Highest blood flow
Lowest blood flow Figure 7: Skin microcirculation images (from highest in red to lowest in blue) in the early morning.
range of L*values in a colour map (Fig 8). The luminosity parameter increased after treatment, indicating the skin was able to reflect more light. Skin roughness in crow’s feet area was
determined by image analysis (Fig 9), through the coefficient of the visibility of wrinkles. The results showed a decrease of 15.4% in this parameter in the crow’s feet area after 28 days.
Conclusion Dawnergy peptide is dual energising and anti-ageing active ingredient developed to meet the needs of active consumers that need to have a better skin complexion in the morning and an adequate level of energy in the skin. By increasing the levels of the JARID1a protein in the early morning, the active ingredient would help advance the activation of diurnal processes. Skin performance and homeostasis were shown to be improved from the beginning of the day in 3D skin models synchronised to circadian rhythms. In addition, the ingredient demonstrates an energising effect on skin fibroblasts, while also modulating mitochondrial complexes activities for anti-ageing benefits. Clinical tests with Dawnergy peptide showed that the natural activation of skin conditions can be advanced in time to improve
0 Days 0 Days 28 Days
Lowest L*
Highest L* Figure 8: Skin luminosity maps of one volunteer before and after treatment.
appearance early in the morning, even despite little rest due to lifestyle factors and that application of the ingredient can help obtain a glowing radiant rejuvenated complexion.
PC 28 Days
References 1 DiTacchio L, Le HD, Vollmers C, Hatori M et al.
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011; 30;333(6051):1881-5
2 Bowman A, Birch-Machin MA. Age-Dependent Decrease of Mitochondrial Complex II Activity in Human Skin Fibroblasts. JID. 136(5):912-9, 2016.
3 Ouslimani N. et al. Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells. Metabolism. 2005; 54(6):829-34.
4 Martin-Montalvo A. et al. Metformin improves healthspan and lifespan in mice. Nat. Commun. 2013; 4: 2192.
Figure 9: Photographs of the crow’s feet area before and after 28days of treatment. PERSONAL CARE ASIA PACIFIC
DAWNERGY™ is owned by The Lubrizol Corporation or its affiliates. © 2019 The Lubrizol Corporation. All Rights Reserved.
September 2019
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