90 SKIN PROTECTION
Skin microbiota: the new era of personal care ingredients
n Federica Carlomagno, Stefania Zanzottera – Roelmi HPC, Italy
This flora lives and transits on the surface and in the superficial layers of the epidermis and down to the hair follicles and glands, forming a complex ecosystem collectively referred as the skin microbiota. This little but important world is essential for the skin to be a complete barrier, accomplishing its activities of protection, immunity and defence.
The skin is the largest organ of the human body in surface and weight, serving as a physical barrier it protects our body from external aggressions. An adult’s skin hosts an average population of 1,000 billion microorganisms among fungi, viruses and bacteria.1,2,3
Each of us has a distinctive combination
of microorganisms all over our body, although scientists point out that the skin microbiome varies a lot intra-personally during our lives, linked to age, change of lifestyle or to the external stresses we are submitted to.4
Abstract
Skin is a complex environment where billions of microorganisms live providing a unique environment for each host, collectively referred to as the skin micriobiota. Skin microbiota is, therefore, the result of an equilibrium between protective and pathogens species of those microorganisms. However, this balance can be easily disrupted by stresses. An alteration of skin microbiota may lead to dysbiosis, which has been associated with skin disorders. The present paper aims to demonstrate the efficacy of a specific selected bacterial strain from cutting-edge biofermentation technology able to maintain skin homeostasis and consequent prevention of skin disorders.
Different body sites can have
completely different skin microbiota configurations, both inter- and intra- personally, linked to the peculiar characteristics of that precise micro- environment. For example, just focusing on the face, studies show that there are great differences between forehead and cheek skin microbiota, due to moist, dry and sebaceous skin sites.5
Despite continuous changes in its composition, when the body is in a homeostatic status, skin microbiota is an
100 80 60 40 20 0
+26.6%
equilibrium between protective and pathogenic microorganisms, living together in a complex community and having a number of different symbiotic interactions. If we consider bacteria, the most important and frequent phyla living on human skin are Actinobacteria, Firmicutes, Proteobacteria and Bacteroidetes, without huge differences among ethnicities. Anyway, going into more specific taxonomic classification, as class or genus or species, we can find differences among peoples’ microbiomes even though looking at subjects with very similar ages, lifestyles, and from the same ethnicities. The general truth for everyone seems to be really that it is the homeostatic condition of skin microbiota with its singular peculiarities that allows a healthy status of the skin. However, everyone’s microbiota balance can be easily disrupted by external and
+21.9% +8.1%
140 120 100 80 60 40 20 0
Medium Salty Water Chlorinated water Medium +
Medium + Artificial water
n CTR- n CTR+ n 1% ÆCTive Figure 1: Cell viability evaluation. PERSONAL CARE ASIA PACIFIC Figure 2: Cell metabolism evaluation. September 2019
internal stresses. A strong change in the environment, for example, can alter skin microbiota leading to its dysbiosis, which has been often associated with skin disorders (skin inflammation, sunburn, dandruff, atopic dermatitis, psoriasis, acne). Avoiding microbiota dysbiosis, i.e. maintaining microbiota equilibrium, may prevent skin disorders. Moreover, it is essential to maintain skin
microbiota’s natural biodiversity in different body sites, in order to let the skin barrier work in the best way possible. Starting from these two fixed points, the development of ingredients that can naturally balance the skin microbiota, while not interacting with its physiological changes and its biodiversity, becomes essential for cosmetic innovation, in order to obtain good performance with the lowest impact on skin homeostasis.
+26.6% +85%
+34.5%
Medium Salty Water
Chlorinated water
Medium +
Medium + Artificial water
n CTR- n CTR+ n 1% ÆCTive
Protein dosage (µg)
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104
