32 ANTI-AGEING
treatment. Moreover, these results were similar to and even better than those obtained after treatment with Ascorbyl Glucoside. Finally, the combination of both active ingredients potentiated the effects compared to the individual use of the benchmark, demonstrating a powerful synergistic effect (Figures 6 and 7). Other analyzed parameters took the same
direction: the active ingredient demonstrated an imqpressive immediate lifting effect (T30 min), which increased along the treatment days (T28) and enhanced the effects elicited by the use of Ascorbyl Glucoside alone. In addition, skin brightening was also
significantly improved by short- (30 minutes) and long-term (28 days) use of the collagen fragment, overmatching benchmark effects and enhancing them when combining the use of the two active ingredients (Figure 7).
Conclusion Collagen is one of the cosmetic industry’s gold ingredients, a quintessential classic. Current demands for sustainable and vegetal resources have made the finding of a collagen fulfilling all these requirements a field of active research. Replying to these requests, LipoTrue has designed an innovative plant-based collagen fragment identical to human type I collagen: Col- Frag remastered. This product is able to achieve greater and immediate anti-ageing, rejuvenating, lifting and brightening effects. Moreover, Col-Frag remastered is able to
enhance the effects elicited by Ascorbyl Glucoside in a synergistical manner, positioning the new product as a remarkable alternative for Vitamin C and its derivatives or to potentiate its actions. Overall, LipoTrue’s active ingredient emerge as
a new sustainable, plant-based, fully functional, highly effective, and identical-to-human choice suitable to be used in improved cosmetic formulations. Col-Frag remastered represents the arrival of a new era, the remastering of the classic type I collagen.
2% COL-FRAG REMASTERED T0 DAYS
T28 DAYS
Vol 5 (55 years old) T0 T30min T28 days
-15.4% wrinkle depth -20.7% wrinkle length
Vol 3 (58 years old)
-10.0% wrinkle depth -5.2% wrinkle length
-32.8% wrinkle depth -12.8% wrinkle length
Figure 6: Pictures of volunteers showing significant reductions in wrinkle crow’s feet length and depth
Implications. Arch. Dermatol. 2008, 144(5):666–672
3. Shoulders MD, Raines RT. Collagen structure and stability. Annu. Rev. Biochem. 2009, 78:929–958
4. Uitto J. Connective tissue biochemistry of the ageing dermis: age-related alterations in collagen and elastin. Dermatologic Clinics. 1986, 4(3), 433-446
PC
References 1. Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the Ageing Skin. Advances in Wound Care. 2013, 2(1), 5–10
2. Fisher GJ, Varani J, Voorhees JJ. Looking Older: Fibroblast Collapse and Therapeutic
WRINKLE DEPTH (crow’s feet, %)
Placebo ■ 2% Col-Frag remastered ■ 2% Ascorbyl Glucoside ■ 1% Col-Frag remastered + 1% Ascorbyl Glucoside ■
-3% -0.11%
-8% ***
-19% *** ***
-14% *** *
-19% *** ***
T30 minutes
-20% *** ***
-21% *** ***
T28 days
-24% *** ***
-0.78% *** *
-0.81% *** *
-0.97% *** ***
-2.08% *** ***
T30 minutes
-1.98% *** ***
T28 days
-2.19% *** ***
Figure 7: Graphs showing skin parameters progression at different timepoints. Note the immediate effects (30 minutes) and the synergia with Ascorbyl Glucoside at all analyzed levels
PERSONAL CARE July 2022
www.personalcaremagazine.com
5. Sionkowska A, Adamiak K, Musiał K, Gadomska, M. Collagen Based Materials in Cosmetic Applications: A Review. Materials. 2020, 13(19), 4217
6. Wang T, Lew J, Premkumar J, Poh CL, Win Naing M. Production of recombinant collagen: state of the art and challenges. Engineering Biology. 2017, 1(1), 18–23
LIFTING (mm)
Placebo ■ 2% Col-Frag remastered ■ 2% Ascorbyl Glucoside ■ 1% Col-Frag remastered + 1% Ascorbyl Glucoside ■
0.22
7. Hopkinson SB, Hamill KJ, Wu Y, Eisenberg JL, Hiroyasu S, Jones JC. Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair. Advances in Wound Care. 2014, Mar 1;3(3):247-263
8. Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. The American Journal of Pathology. 2006, 168(6), 1861–1868
9. Fujimura T, Moriwaki S, Imokawa G, Takema Y. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. J. Dermatol. Sci. 2007, Jan;45(1):45-53
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