Plenary Special Lectures 33


Figure 1. STED microscopy reveals densely packed NV centers inside a diamond crystal. Confocal ~left! and STED ~middle! image of the same crystal region. The coordinate of each center ~right! is established with 1.4 Angström precision; see Ref @5#.


Figure 2. Multicolor nanoscopy imaging with STED and GSDIM. The first two images compare a STED image revealing Lamin ~blue!, Clathrin ~red! and Tubulin ~green! with its confocal reference. Similarly, the right hand side images compare a 2-color GSDIM image showing microtubules ~green! and peroxysomes ~red! with its conventional epifluorescence counterpart.


Biography of StephanW.Hell


In 1981 StefanW. Hell began his studies at the University Heidelberg ~Germany!, where he received his doctorate in physics. His thesis advisor was the solid-state physicist Siegfried Hunklinger. From 1991 to 1993 Hell worked at the EuropeanMolecular Biology Laboratory in Heidelberg and from 1993 to 1996 he worked as a group leader at the University of Turku ~Finland! in the department for Medical Physics, where he developed the principle for stimulated emission depletion STED microscopy. He received his habilitation in physics from the University of Heidelberg in 1996, and the following year became a group leader of his current research group dedicated to sub-diffraction-resolution microscopy at the Max Planck Institute for Biophysical Chemistry in Göttingen. On October 15, 2002 Hell became a director of theMax Planck Institute for Biophysical


StephanW.Hell


chemistry and he established the department of Nanobiophotonics. Since 2003 Hell has also been the leader of the department “High Resolution Optical Microscopy division” at the German Cancer Research Center ~DKFZ! in Heidelberg.


With the invention and subsequent development of STED microscopy and related microscopymethods,Hell was able to


show that one can substantially improve the resolving power of the fluorescence microscope. Hell was the first to demonstrate, both theoretically and experimentally, how one can decouple the resolution of the fluorescence microscope from diffraction and increase it to a fraction of the wavelength of light ~to the nanometer scale!. For this achievement and its significance for other fields of science, such as the life-sciences and medical research, he received the 10th German Innovation Award ~Deutscher Zukunftspreis! in November 2006.


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