Chapter 17 Implications of Drug-Nutrient Interaction and Pharmacology

TABLE 17.2 cont. Drug Classes and Treatment Uses Class of Drug

Antihyperlipidemic Antihypertensive

For Treatment of High cholesterol

High blood pressure

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Examples

Statins, lovastatin (Mevacor)

Beta-blockers (atenolol, propranolol,

metoprolol, sotalol, carvedilol), hydralazine, clonidine

Anti-inflammatory Fever, inflammation Corticosteroids,

naproxen, ibuprofen, indomethacin, colchicine

Other Information

Take with food to increase absorption.

Depletes CoQ10

Grapefruit juice increases drug absorption.

Avoid natural licorice.

Milk or food decreases GI irritation.

Avoid alcohol.

Can decrease selenium, calcium, vitamin D, potassium, zinc, folic acid, iron

Antineoplastic Cardiovascular Diuretic Cancer Heart Water retention Methotrexate Digoxin, potassium

Furosemide (Lasix), loop diuretics

Hydrochlorothiazide (HCTZ), indapamide, metolazone, chlorthalidone

Laxative Constipation

Polycarbophil (FiberCon,

Mitrolan), mineral oil

Psychotherapeutic Anxiety, depression

MAOIs, isocarboxazid, tranylcypromine, phenelzine

a www.cc.nih.gov/ccc/patient_education/drug_nutrient/coumadin1.pdf

Can decrease folic acid, vitamin B-12

Depletes thiamin, magnesium, vitamin B-12

Increases mineral loss; include fresh fruits and vegetables

Depletes folic acid, CoQ10, calcium, zinc

Decreases nutrient absorption Can decrease vitamins A, D, E, K; potassium; beta-carotene

Avoid foods high in tyramine.