Chapter 13 Nutritional Aspects of Diabetes

TABLE 13.3 Action Times of Human Insulin Preparations Type of Insulin

Onset of Action

Rapid-Acting (Insulin Analog)

Insulin lispro (Humalog) Insulin aspart (NovoLog) Insulin glulisine (Apidra)

Short-Acting Regular (Humulin R and Novolin R) Intermediate-Acting

NPH (neutral protamine Hagedorn) (Humulin N and Novolin N)

Long-Acting

Insulin glargine (Lantus) Insulin detemir (Levemir)

Mixtures

70/30 (70% NPH, 30% regular) (Humulin 70/30 and Novolin 70/30) Humalog mix 75/25 (75% neutral protamine lispro [NPL], 25% lispro) Humalog mix 50/50 (50% protamine lispro, 50% lispro

Novolog mix 70/30 (70% neutral protamine aspart [NPA], 30% aspart)

Source: Adapted with permission from Burant CF, Young LA. Medical Management of Type 2 Diabetes. 7th ed. Alexandria, VA: American Diabetes Association; 2012.

0.5–1 hr < 0.25 hr < 0.25 hr < 0.25 hr

Dual Dual Dual Dual

10–16 hr 10–16 hr 10–16 hr 10–16 hr

2–4 hr

0.8–2 hr (dose dependent)

Peakless Peakless

20–24 hr

12–24 hr (dose dependent)

10–12 hr 10–12 hr

2–4 hr 4–10 hr 10–16 hr 8–12 hr 0.5–1 hr 2–3 h 3–6 hr ~4 hr (next meal)

< 0.25–0.5 hr < 0.25 hr < 0.25 hr

0.5 to 2.5 h 0.5–1 hr 1–1.5 hr

3–6.5 hr 3–5 hr 3–5 hr

1–2 hr 1–2 hr 1–2 hr

183

Peak Action

Usual Effective Duration

Monitor Effect In