Chapter 17 Implications of Drug-Nutrient Interaction and Pharmacology TABLE 17.1 The Four Parameters of Pharmacokinetics
Parameter Absorption
Increases in Older Adult
Blood levels of water-soluble drugs Gastric pH
Malabsorption
Decreases in Older Adult Absorptive surface Gastric emptying
Gastric secretion GI motility
Pancreatic trypsin Splanchnic blood flow
Distribution Body fat Serum cx-glycoprotein
Blood levels of fat-soluble drugs
Metabolism
Cardiac output Cerebral blood flow Drug binding Lean body mass Serum albumin Total body water Hepatic blood flow
Hepatic mass Excretion
Glomerular filtration Renal blood flow Tubular secretion
Membrane permeability
Increase/Decrease Dependent on Specific Drug
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Enzyme activity, inducibility
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