SKIN PROTECTION
which can enter the skin through an impaired skin barrier. The influence of the new yeast cell active on the adhesion of bacteria to skin was investigated using a RHE model. The amount of radiolabelled S. aureus present on washed RHE was compared between RHE treated with PBS (control) and treatment with different concentrations of the new yeast cell active. A strong concentration-dependent inhibitory effect of the new yeast cell active on the adhesion of S. aureus on RHE was observed (Fig. 3).
Restoration of skin barrier, hydration and wellbeing
In order to test the efficacy of the new yeast cell active in vivo, a double-blind, placebo controlled clinical study was performed with volunteers that were diagnosed with AD. Topical application of the new yeast cell active for 28 days significantly increased skin hydration, smoothness and reduced TEWL (Figs. 4-6), resulting in a less irritated skin with an improved barrier function. In a second clinical study, volunteers suffering from AD rated different aspects of their skin condition of a body part with eczema using a 10-point scale ranging from best (no disturbances at all) to worst (frequent and important occurrence
Lipstick is Important!
of skin disturbances). After 7 days of treatment with an aqueous solution of the new yeast cell active, a significant improvement in several visual and perceived aspects of the eczematous skin was reported by the volunteers (Fig. 7). The highest positive change was observed for the self assessment of redness and roughness of the skin. Due to these improvements, 70% of the volunteers also reported a significant increase of general wellbeing of their skin.
Conclusion
MgCM-Glucan is an active designed to rebalance the skin’s immune system by repressing the Th2 path, which became overactive in our modern, clean world. As a result, MgCM-Glucan was able to reduce the extent of Th2-mediated immune response and impair adhesion of S. aureus to the skin in vitro. Experiments in vivo showed that MgCM- Glucan improves the skin barrier and hydration to help those suffering from oversensitised dry skin to feel more comfortable in their own skin.
References 1 Handout on health: atopic dermatitis (a type of eczema). National Institute of Arthritis and Musculoskeletal and Skin Diseases. 2013.
2 Flohr C, Pascoe D, Williams HC. Atopic dermatitis and the ‘hygiene hypothesis’: too clean to be true? Br J Dermatol 2005; 152 (2): 202-16.
3 Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299 (6710): 1259-60.
4 Zhu J, Paul WE. CD4 T cells: fates, functions, and faults. Blood 2008; 112 (5): 1557-69.
5 Brandt EB, Sivaprasad U. Th2 cytokines and atopic dermatitis. J Clin Cell Immunol 2011; 2 (3): 110.
6 Liu FT, Goodarzi H, Chen HY. IgE, mast cells, and eosinophils in atopic dermatitis. Clin Rev Allergy Immunol 2011; 41 (3): 298-310.
7 Kimata H, Lindley I. Detection of plasma interleukin-8 in atopic dermatitis. Arch Dis Child 1994; 70 (2): 119-22.
8 Dokmeci E, Herrick CA. The immune system and atopic dermatitis. Semin Cutan Med Surg 2008; 27 (2): 138-43.
PC
9 Haapakoski R, Karisola P, Fyhrquist N et al. Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms. J Invest Dermatol 2013; 133 (4): 964-72
10 Kirmaz C1, Bayrak P, Yilmaz O, Yuksel H. Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur Cytokine Netw 2005; 16 (2): 128-34.
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www.siltechpersonalcare.com February 2016 PERSONAL CARE 67
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