COVER STORY: SESDERMA ADVERTISEMENT FEATURE 7


How Sesderma is continuing to pioneer in personal care in 2026


Dr. Gabriel Serrano Sanmiguel – Sesderma


In 1989, I founded Sesderma Laboratories with the mission of transforming dermatological research into effective, accessible, and personalized skincare solutions. I have been a pioneer in several fields


of dermatology and cosmetic science— introducing glycolic acid, chemical peels, and microdermabrasion protocols in Spain, and later, in 2008, becoming one of the first to apply nanoliposome technology to dermocosmetics. This proprietary technology, developed


entirely in our own laboratories, is based on advanced encapsulation methods that allow actives to reach their biological targets with unprecedented precision. Unlike traditional creams that remain on the


surface, Nanotech encapsulates each active ingredient in biocompatible, biodegradable lipid vesicles smaller than 100nm, whose structure mimics the skin’s own cell membranes. This design enables actives to cross the stratum corneum intact, delivering them gradually and effectively where they are needed most. The result is greater efficacy, enhanced stability, and exceptional tolerance—even with molecules that are typically irritating such as retinoids or acids. Our encapsulation platform allows us to


formulate both hydrosoluble actives (vitamin C, niacinamide, hyaluronic acid, glycolic acid, growth factors, EGCG, lactoferrin) and liposoluble ones (vitamin E, vitamin D, ferulic acid, retinoids), ensuring complete and synergistic skin treatment. Independent in-vitro studies have shown that liposomal retinol is up to 21 % more effective in collagen synthesis than free retinol, and that liposomal azelaic acid achieves superior depigmenting action with greater safety at lower concentrations. Beyond improving penetration,


Nanotech liposomes provide controlled release over time, delivering both immediate and long-term benefits while reinforcing the skin barrier. They also exhibit intrinsic epithelial- repair, antioxidant, and sebum- regulating properties. Importantly, Sesderma designs and manufactures its own liposomes—without intermediaries— ensuring total control of composition, size, and performance.


Continuing innovation with nanotech Fifteen years later, this pioneering innovation continues to define our identity. Nanotech is not


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Biocogent on the capacity of skin cells to be more effective at taking care of themselves


RNA-BASED ‘TEXT MESSAGE’ SKIN CARE


just a technology—it is a philosophy of precision dermatology, now evolving into exosome-based systems that push the boundaries of molecular regeneration. At Sesderma, we structure our innovation


not by product type, but by skin need—ageing, pigmentation, hydration, or sensitivity—so every line contributes to a unified dermatological ecosystem.


This approach allows us to develop synergistic


and personalized regimens. Our latest generation of serums, The Power of 5, illustrates this perfectly. RETI AGE 5 combines five retinoids encapsulated in liposomes for powerful rejuvenation with high tolerance. C-VIT 5 brings together five stabilized forms of vitamin C for radiance and antioxidant protection. HIDRADERM HYAL 5 provides multilayer hydration through five molecular weights of hyaluronic acid. Building on this legacy, we recently introduced


EXOSES, the first Sesderma dermocosmetic line formulated with Lactobacillus-derived exosomes, capable of enhancing cellular communication and regeneration. This innovation represents the natural evolution of our liposomal Nanotech system—transforming delivery technology into true molecular dialogue with the skin. In parallel, our nutricosmetics division is


rapidly advancing, focusing on molecules that complement topical care through systemic benefits. We are currently developing Lactoferrin- based formulations in multiple applications— Defense (immune and infectious protection), Cognitive (neurological and mental support), and Longevity (combined with zinc and vitamin D3 for anti-ageing


resilience). Additionally, we are reintroducing liposomal Glutathione, a potent antioxidant and detoxifier, and creating liposomal Magnesium in advanced forms such as magnesium gluconate and magnesium bisglycinate, for optimal absorption and neuromuscular balance. Together, these developments illustrate Sesderma’s holistic approach—integrating biotechnology, dermatology, and systemic wellness—to


January 2026 PERSONAL CARE MAGAZINE WWW.PERSONALCAREMAGAZINE.COM


PERSONAL MAGAZINE


Helena Rubinstein: Combining science and luxury


JANUARY 2026 VOL 27 ISSUE 1


The Amazon’s liquid gold


Cacay:


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