ANTI-AGEING 65
The combined results highlight the dual cosmetic potential of Natix Angelica root essential oil, positioning it as a high-value natural activity for the anti-ageing skin care market. By demonstrating potent elastase inhibition
together with a marked stimulation of collagen I synthesis, the ingredient directly targets two key biological mechanisms of skin ageing—loss of elasticity and reduced dermal matrix integrity. This translates into firmer, smoother skin and positions the oil as a competitive natural alternative to synthetic actives in the premium anti-ageing segment. The strong lipoxygenase inhibition reflects
a robust capacity to modulate inflammatory pathways, addressing redness, irritation, and stress-induced skin ageing. This dual soothing effect not only enhances
consumer comfort but also reinforces the positioning of the oil in the growing “sensitive skin + anti-ageing” category, a major driver of innovation in natural cosmetics. Overall, the convergence of scientific
validation and consumer demand for natural, multifunctional ingredients makes Natix Angelica root essential oil a powerful differentiator for brands seeking to combine efficacy, naturality, and market relevance in their next-generation formulations. This natural ingredient from Natix therefore
represents a valuable functional active for cosmetic formulations targeting firmness, elasticity, and skin comfort, meeting the specific needs of mature and sensitive skin.
References 1. Coleman SR, Grover R. The anatomy of the aging face: volume loss and changes in 3-dimensional topography. Aesthet Surg J. 2006; Jan-Feb; 26(1S):S4-9
2. Dwivedi S et al. Evolution of consumer perceptions and intentions in the green cosmetics market: a thematic and trend analysis, Review. Frontiers in Sustainability. Sec. Sustainable Consumption Volume 6 – 20 Aug 2025
3. Friedman O. Changes associated with the aging face. Facial Plast Surg Clin North Am. 2005; 13, 371–380
4. Ganceviciene R et al. Skin anti-aging strategies. Dermato-Endocrinology. 2012;4(3):308–319
5. Griffin MF et al. Understanding the impact of fibroblast heterogeneity on skin fibrosis. Dis Model Mech. 2020; Jun 15;13(6)
6. Kazanci A et al. Analyses of changes on skin by aging. Skin Res Technol. 2016;23(1):48–60
7. Liu JH et al. Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase Planta Med. 1998; Aug;64(6):525-9
8. Mora Huertas AC et al. Molecular-level insights into aging processes of skin elastin. Biochimie. 2016;128–129:163–173
9. Quan T, Fisher GJ. Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: A mini review. Gerontology. 2015; 61:427–434
10. Shin JW et al. Molecular Mechanisms of Dermal
www.personalcaremagazine.com Cell Viability (MTT) - NHDF (48h)
125 100 75 50 25 0
Control 0.001%
Figure 2: Effects on cell viability. Bar graph representing relative cell viability, after 48 hours of treatment in NHDFs with Angelica oil at 0.001%
125 100 75 50 25 0
PCM 150 Control ELN/cell Viability - NHDF (48h)
COL1A1/cell viability - NHDF (48h) *
0.001%
100
50
0 Control 0.001%
Figure 3: Effects on the synthesis of collagen I (COL1A1) and elastin (ELN), normalized to cell viability. Bar graph representing secreted pro-collagen I type A (COL1A1) and elastin (ELN) protein levels normalized to cell viability, after 48 hours of treatment in NHDFs
Aging and Antiaging Approaches. Int J Mol Sci. 2019;20(9):2126
11. Taylor KR, Gallo RL. Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. FASEB J. 2006; Jan 20(1):9-22
12. Tigges J et al. The hallmarks of fibroblast ageing. Mech Ageing Dev. 2014; Jun; 138:26-44
13. Wei A, Shimamoto T. Antioxidant/lipoxygenase inhibitory activities and chemical compositions of selected essential oils. J Agric Food Chem. 2010; Jun 23;58(12):7218-25
14.. Wlaschek M et al. Connective Tissue and Fibroblast Senescence in Skin Aging. J Invest Dermatol. 2021 Apr;141(4S):985-992
15. Xia W et al. A mouse model of skin aging: fragmentation of dermal collagen fibrils and reduced fibroblast spreading due to expression of human matrix metalloproteinase-1. J Dermatol Sci. 2015; Apr; 78(1):79-82
16. Hong Y-H et al. Physiological effects of formulation containing tannase-converted green tea extract on skin care: physical stability, collagenase, elastase, and tyrosinase activities. Integrative Medicine Research. 2014, 3(1):25-33
17. Zeng JP et al. Repeated exposure of mouse dermal fibroblasts at a sub-cytotoxic dose of UVB leads to premature senescence: a robust model of cellular photoaging. J Dermatol Sci. 2014 Jan; 73(1):49-56
January 2026 PERSONAL CARE MAGAZINE
ELN/cell viability (%)
COL1A1/cell viability (%)
Relative cell viability (%)
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72
