60 RETINOL ALTERNATIVES
Figure 2: Oleosome-Growth Factors delivered statistically superior results in wrinkle depth and wrinkle length in just 14 days
From a regulatory standpoint, molecular
farming-derived growth factors are classified as recombinant proteins of plant origin, supporting vegan and clean-label claims. INCI listings can emphasize both biotechnology and natural delivery, aligning with consumer demand for transparency. By avoiding mammalian cells, these systems also circumvent safety debates associated with serum-derived proteins.
Sustainability and scalability: building the future of beauty The combination of molecular farming and oleosome delivery represents step-change innovation. ■ Ethical sourcing: 100% vegan, animal-free, and free from human or microbial cell systems. ■ Resource efficiency: Year-round greenhouse cultivation with minimal land and water use. ■ Carbon reduction: Avoids solvent-intensive fermentation, aligning with climate goals. ■ Traceability: Closed-system production ensures transparency and consistency. ■ Life cycle perspective: Molecular farming reduces greenhouse gas emissions by up to 80% compared with traditional fermentation, with optimized water use and minimal land input. Camelina sativa thrives on marginal soils unsuitable for food crops, avoiding agricultural competition. Global beauty brands under pressure to meet 2030 sustainability targets can integrate molecular farming to reduce environmental impact while enhancing ESG reporting.
Market and consumer implications Consumers increasingly demand products that are scientifically validated, deliver exceptional results, and are eco-conscious. Oleosome-Growth Factors deliver on all fronts. The clinical trial results highlighted superior performance against retinol,
PERSONAL CARE MAGAZINE January 2026
long regarded as the benchmark for anti-ageing. The Oleosome-Growth Factors delivered
statistically superior results in wrinkle depth, wrinkle length, skin smoothness, and brightness— and did so faster, with visible improvements as early as day 14. Core Biogenesis aims to create a more
sustainable future by using a plant-based platform to produce high-value recombinant proteins in a repeatable, scalable and cost-effective way. Thus, the company’s use of the camelina seed
to deliver its biomimetic growth factors, using molecular farms supports both its mission and consumers’ demands for skin care made with non- toxic, natural ingredients. Most importantly, the company has
developed a product that is both effective and eco-conscious; many brands deliver on part of these claims but not both. The use of Oleosome Growth Factors provides a compelling story for formulators and consumers alike. By making high-performance growth factors
scalable and accessible, molecular farming democratizes advanced anti-ageing solutions. This shift could reshape the category, offering alternatives for sensitive skin users often excluded by irritant-driven actives like retinoids.
Conclusion The anti-ageing skin care sector is undergoing a profound transformation. Retinoids have long served as the benchmark, but their limitations have opened opportunities for innovation. Oleosome- fused, plant-derived growth factors offer faster, clinically superior results delivered sustainably and without irritation. Core Biogenesis’ integration of molecular
farming and oleosome delivery provides a blueprint for regenerative beauty. By uniting biotechnology, sustainability, and clinical validation, formulators can move beyond incremental improvements to
transformative skin care. The era of irritant-driven renewal is giving way to
regenerative, biologically intelligent interventions— skin care that works with biology, powered by plants, delivering results that are visible, sustainable, and scientifically undeniable.
References 1. McKinsey & Company. The State of Fashion: Beauty. Volume 2. June 2025
2. Drive Research. Drive Research Skincare Survey. June 13–24, 2023
3. Drive Research. Drive Research Ski care Survey. June 13–24, 2023
4. Emily Levin, MD. Retinol and Sensitive Skin. Northwest Dermatology Group. January 16, 2023
5. Explorer Research. Sustainability 2024 Shopper Insights Report. May 16, 2024
6. AbiCh Lifeanalytics. Final Report: Evaluation of the Anti-Wrinkle, Firming, Depigmenting Efficacy, and Barrier Effect of A Cosmetics Product. July 26, 2024
7. Yousefian F, Espinoza L, Yadlapati S, Lorenc ZP, Gold M. A Comprehensive Review of the Medical and Cosmetic Applications of Exosomes in Dermatology. Journal of Cosmetic Dermatology. January 16, 2024
8. Villarreal-Gómez LJ, Origel-Lucio S, Hernández-Hernández DA, Pérez-González GL. Use of Exosomes for Cosmetics Applications. Cosmetic Dermatology. January 13, 2025
9. Core Biogenesis. Peauforia + Peauvita: Oleosome-Encapsulated Growth Factors in Clinical Anti-Aging Skin care vs 0.3% Retinol. Parallel-Arm Clinical Study Report. 2025
10. US Food & Drug Administration (FDA). Consumer Alert on Regenerative Medicine Products Including Stem Cells and Exosomes. July 22, 2020
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