48 MARINE INGREDIENTS
Tetaselmis biomass
Active molecule of the microalga
Saccharomyces
Enzymatic hydrolysis
Figure 2: Production process of TetraGold
Enhanced hyaluronic acid synthesis and preservation One of the hallmark benefits of the dual bioactivated Tetraselmis suecica ferment is its ability to increase the skin’s own production of hyaluronic acid while simultaneously protecting existing HA from degradation. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan in the skin’s extracellular matrix, is renowned for its extraordinary capacity to bind water—up to 1,000 times its own weight. This remarkable moisture retention underpins its critical role in maintaining skin hydration, turgor, and viscoelasticity.6 Endogenous HA content naturally declines
with age, which contributes to loss of moisture and firmness in ageing skin. Therefore, strategies to boost endogenous HA synthesis are highly desirable for anti-ageing skin care, as they can replenish the dermal extracellular matrix and improve skin moisture from within. In vitro studies on human dermal fibroblasts
treated with the fermented T. suecica microalgal extract showed a significant increase in HA production. Specifically, fibroblast cultures exposed to 1–2% of the extract for 24 hours exhibited up to a 17% increase in HA synthesis compared to untreated cells.4 This is a noteworthy enhancement, given that
even a small increase in HA can greatly improve tissue hydration. The bioactivated extract likely contains released algal polysaccharides or oligosaccharides and yeast-derived signaling molecules, which stimulate fibroblasts and keratinocytes to upregulate HA synthase enzyme expression or activity. By delivering bioavailable fragments and
bioactives, the ferment effectively stimulates the skin to generate new HA, helping compensate for age-related HA loss. Equally important, the extract has shown
ability to help preserve hyaluronic acid in the skin by inhibiting the enzyme hyaluronidase.
Hyaluronidases are responsible for continually breaking down HA in the dermis; in fact, native HA in skin has a rapid turnover - its half-life in the skin is less than one day - due to enzymatic degradation.7 Inhibition of hyaluronidase can slow
this turnover, allowing HA to remain longer in the tissue. Enzyme assays demonstrate that the fermented T. suecica extract (at 2.5% concentration) inhibited about 57% of hyaluronidase activity, compared to control, thus preserving over half of the HA from degradation.4 This level of inhibition is quite substantial
and, according to the supplier, outperforms standard antioxidants like vitamin C in the same assay.4
Mechanistically, flavonoids, terpenoids,
and polyphenols released from the microalgae or produced during fermentation may be responsible, as many of these natural compounds are known to act as hyaluronidase inhibitors to varying degrees. The ferment’s broad spectrum
Saccharomyces fermentation
+17% 115
TetraGold 5% 105
TetraGold 2.5% TetraGold 1% Vitamin C 15mM Gallic Acid 40mM
Resveratrol 50mg/l CTL Negative
95 NC 1 TetraGold®%
Figure 3: Hyaluronidase enzyme inhibition PERSONAL CARE MAGAZINE January 2026
2 0 10 20 30 40 50 % of non-degraded HA Figure 4: Hyaluronic acid stimulation
www.personalcaremagazine.com 60 70 21%
61% 57% 51%
40% 38%
HA (% of NC)
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