50 MARINE INGREDIENTS The ability to control sebum while
simultaneously providing anti-ageing hydration is a unique and valuable feature for a cosmetic active. The fermented microalgal extract exhibits significant sebum-regulating activity, making it highly relevant for oily and combination skin types that also experience ageing. In vivo efficacy was demonstrated in a 28-
day clinical study on 20 volunteers with oily or combination skin. Subjects applied a formula containing the microalgal ferment twice daily, and their facial sebum levels were measured by Sebumeter. After 14 days, the product had already led to a 16% reduction in skin sebum, and by 28 days a 21% reduction in sebum production was observed on average.4 From a formulator’s perspective, this dual
action of hydrating while mattifying is highly attractive. It enables the design of anti-ageing products for populations like menopausal women who might still experience adult acne or oily T-zones, or for any individual seeking age- defying benefits without the heavy or greasy feel that many rich anti-wrinkle creams impart. By incorporating the fermented T. suecica extract, a formulation can provide a shine-controlling, pore-refining effect alongside wrinkle-smoothing hydration.
The study’s 21% sebum reduction in a
month is comparable to some dedicated sebum-control actives, yet here it is achieved as part of a broader anti-ageing treatment. This multifunctionality means fewer separate products or ingredients are needed to address both wrinkles and oiliness. Using a single bioactivated extract might replace multiple ingredients (hydrators, sebum regulators, antioxidants), simplifying formulations and avoiding potential compatibility issues.
Benefits of TetraGold
Conclusion In conclusion, the dual bioactivated Tetraselmis suecica fermentate exemplifies how advanced enzymatic and probiotic technologies can unveil a new level of efficacy from natural ingredients. By combining enzymatic hydrolysis (to release and activate microalgal compounds) with Saccharomyces boulardii fermentation (to enrich the extract with potent postbiotics), multiple anti-ageing effects addressing both the cause and effect of skin ageing can be achieved. Stimulating endogenous hyaluronic acid
production and safeguarding it from degradation can boost the skin’s own regenerative capacity which in turn yields improved hydration, plumpness and wrinkle reduction from within. Through stimulation of endogenous
hyaluronic acid production and protection against hyaluronidase-driven degradation, a deeper, longer-lasting hydration and firmness can be supported—tackling one of the root causes of wrinkle formation and loss of elasticity. At the same time, its clinically demonstrated
seboregulating activity provides targeted benefits for oily and combination ageing skin, helping to refine pores, reduce shine, and maintain balance without compromising hydration. For formulators, such innovation offers a rare combination of efficacy, versatility, and
PERSONAL CARE MAGAZINE January 2026
sustainability: a single bioactivated ingredient that can simplify product design by replacing multiple actives while aligning with clean beauty expectations. Beyond its direct benefits for ageing skin,
it also reflects a broader paradigm shift in cosmetic science—leveraging fermentation and bioconversion to enhance potency, bioavailability, and eco-responsibility. Ultimately, this innovation demonstrates
how supporting the skin’s own regenerative capacity—rather than relying solely on topical supplementation—can achieve more integrated and durable results. As consumer demand grows for high-performance yet sustainable solutions, bioactivated marine fermentates like this one point toward the future of anti-ageing skin care: holistic, multifunctional, and rooted in both nature and advanced science.
References 1. Majchrzak W, Motyl I, Śmigielski K. Biological and Cosmetical Importance of Fermented Raw Materials: An Overview. Molecules. 2022, 27, 4845
2. Referring to: TetraGold® bioactivated cosmetic active ingredient derived from microalgae. Produced by Active Cells Biotechnology
3. Jo WS et al. Effect of Microalgal Extracts of Tetraselmis suecica against UVB-Induced Photoaging in Human Skin Fibroblasts. Toxicol Res. 2012 Dec;28(4):241–248
4. Active Cells Biotechnology. Information brochure about TetraGold® cosmetic bioactive ingredient. Unpublished report, 2025
5. Fu JJ et al. Unique Probiotic Properties and Bioactive Metabolites of Saccharomyces boulardii. Probiotics Antimicrob Proteins. 2023; Aug;15(4):967-982
6. Liu K, Nassim J. The hype on hyaluronic acid. Harvard Health Publishing. 23 January 2020.
https://www.health.harvard.edu/blog/the- hype-on-hyaluronic-acid-2020012318653
PCM
7. Žádníková P, Šínová R, Pavlík V, Šimek M, Šafránková B, Hermannová M, Nešporová K, Velebný V. The Degradation of Hyaluronan in the Skin. Biomolecules. 2022, 12(2), 251
8. Giardina S, Poggi R. Skin Penetration Ability of 12 Hyaluronic Acids with Different Molecular Weights After Topical Application. Journal of Dermatology & Clinical Research, Juniper Publishers, 2023. https://juniperpublishers. com/jojdc/pdf/
JOJDC.MS.ID.555665.pdf
9. Draelos ZD. Efficacy evaluation of a topical hyaluronic acid serum. Journal of the American Academy of Dermatology. 2021; 85(3), AB73
www.personalcaremagazine.com Sebaceous hypersecretion Effect of ageing
Collagen
Hyaluronidase Elastin
Fibroblast Hyaluronic acid
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72
