58 RETINOL ALTERNATIVES BEFORE AFTER 14 DAYS AFTER 30 DAYS
Figure 1: Visible results in fine lines and wrinkles from Oleosome-Growth Factors at 14 days and 30 days
proprietary platform to fuse biomimetic growth factors with camelina seed-derived oleosomes, creating two novel actives, Peauvita (Oleosome- EGF) and Peauforia (Oleosome-FGF-2) (also referred to as Oleosome-Growth Factors). These biomimetic Oleosome-Growth
Factors have demonstrated clinically validated superiority to retinol while offering a sustainable and environmentally friendly future for skin regeneration. This commitment to sustainability is further
reflected in the Ecovadis Platinum Sustainability Medal awarded to Core Biogenesis—an assessment that places the company within the top one percent of businesses evaluated globally for their performance across environmental, labour and human rights, ethical, and sustainable- procurement criteria.
Oleosomes: Nature’s advanced delivery system Core Biogenesis’ biomimetic solution is based upon the use of oleosomes, which are spherical, lipid-based organelles naturally found in oil-rich seeds. Oleosome technology has been used in the skin care and cosmetic industry for over two decades. However, Core Biogenesis has innovated the way that oleosomes are featured, leveraging
Oleosome-Growth Factor
these structures as delivery systems for growth factors. Structurally, oleosomes contain a
triacylglycerol core surrounded by a phospholipid monolayer embedded with oleosins. This architecture confers remarkable stability, stress resistance, and controlled release of their contents. For topical skin care, oleosomes provide
multiple advantages: ■ Molecular protection: Fused proteins retain >92% bioactivity over 12 weeks, compared with 8% for ‘naked’ proteins. ■ Biocompatibility: Their lipid composition mirrors the skin’s own matrix, enhancing dermal penetration. ■ Sustained release: Oleosins are gradually degraded by skin proteases, ensuring controlled, physiologically timed delivery. Unlike synthetic encapsulation systems such as liposomes or polymeric nanoparticles, oleosomes are natural, biodegradable, and label-friendly, perfectly aligned with consumer demand for ‘clean’ and sustainable beauty. Mechanistically, the breakdown of oleosins by proteases mirrors the skin’s natural renewal processes, supporting enhanced efficacy while minimizing immune responses or allergic reactions.
TABLE 1: OLEOSOME-GROWTH FACTORS COMPARED TO EXOSOMES Property
Efficacy Ethical Sourcing Safety and Penetration Stability Sustainability
Peauvita and Peauforia are bioidentical to human growth factors, activating pathways for collagen I synthesis, skin repair, and pigmentation regulation, translating to faster, more visible anti-ageing results6
Produced entirely in closed greenhouse systems in France, these actives are 100% vegan
By mimicking the skin’s lipid structure, oleosomes allow active proteins to penetrate the epidermis and dermis effectively while minimizing systemic absorption7
Eight to ten times more stable than undelivered proteins, retain- ing over 92% of bioactivity in a 12-week study6
Plant-based biofactories enable traceable, year-round produc- tion with minimal land, water, and carbon impact
PERSONAL CARE MAGAZINE January 2026 Exosomes
Research and clinical studies are needed to understand exosomes full potential in topical skin care7
Other growth factors or exosomes may include non-plant cells
Non-plant-derived growth factors may carry uncertain safety pro- files due to their sourcing from human, animal, or microbial cells7
Highly sensitive to environmental conditions, complicating formu- lation8
Exosomes currently lack clear regulatory guidelines; thus, under- standing sourcing is a factor for brands and formulators10
www.personalcaremagazine.com For formulators, oleosomes simplify product
architecture, enabling high-performance formulations with fewer excipients—an advantage in the era of minimalist, transparent skin care. This natural, biomimetic delivery system also facilitates consistent bioavailability, reducing the variability often observed with conventional encapsulation methods.
Comparing oleosome growth factors with exosomes Exosomes are gaining attention for their regenerative potential. They are cell-derived vesicles containing a complex mix of proteins including RNAs and lipids, and while they hold promise in clinical medicine, their use in cosmetics is not regulated. Their biological complexity and variability make them hard to standardize, and sourcing from human, animal, or microbial cells introduces ethical, regulatory, and safety concerns. They are not bioidentical, and their mechanism of action in topical skin care is still not fully understood.
Clinical validation: Oleosome- Growth Factors vs. retinol To benchmark performance, Core Biogenesis conducted a 60-day, randomized, head-to-head
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