C
N
E
I
L
E
A
B
R MENOPAUSAL SKIN CARE 89
65 60 55 50 45 40
SKIN HYDRATION ***
** +9% +23% 61 56 54 51 50 50
9.5 9
8.5 8
preM placebo d0 d28 postM placebo d0 d28 postM 5% NA d0 d28 preM placebo Figure 7: Effect on transepidermal water loss (TEWL) and skin hydration in pre- and post-menopausal women PROLINE
2.5 2.0 1.5 1.0 0.5 0
preM placebo d0 d28 p<0.05* p<0.06 +81% -23%
400 350 300 250 200 150 100 50 0
postM placebo d0 d28 postM 5% NA Figure 8: Influence on collagen degradation in post-menopausal skin
versus placebo as seen in Figure 7, indicating protection against collagen breakdown and support for new collagen synthesis. This result suggests that our vitamin B3 helps
in improving skin firmness and reduction of wrinkles. It additionally contributes to age spot reduction by inhibiting melanin transfer and enhancing the efficacy of other skin-lightening actives, enabling powerful combinations to be formulated for improved skin tone and age spot reduction.
Conclusion These groundbreaking new studies not only confirm that DSM-Firmenich’s niacinamide active boosts ceramides but reveal for the first time that it can re-balance ceramides composition back to pre-menopausal levels. The multi-functional properties of
this vitamin enable menopausal skin concerns to be addressed by one active working through many mechanisms, which result in improved hydration, restored barrier function, enhanced DNA repair, support in protecting against UV damage and environmental stressors, boosted collagen production and reducing age spots that together lead to healthier skin. Its natural origin and eco-conscious,
sustainable production make it the key active for menopausal beauty products and a testament to DSM-Firmenich’s commitment to scientific innovation for consumer health and wellbeing at all stages of life.
PC
References 1. Zouboulis CC, Blume-Peytavi U, Kosmadaki M, Roó E, Vexiau-Robert D, Kerob D, Goldstein SR. Skin, hair and beyond: the impact of menopause. Climacteric. 2022;25(5):434-442
2. Moore DJ, Rawlings AV. The chemistry, function and (patho)physiology of stratum corneum barrier ceramides. Int J Cosmet Sci. 2017;39(6):366-372
3. Kahraman E, Kaykın M, Şahin Bektay H, Güngör S. Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin. Cosmetics 2019, 6, 52
d0 d28 preM placebo d0 p<0.06
ACETYLPROLINE p<0.01
d0 d28 postM placebo d0 d28 postM 5% NA d0 d28 9.4
13
12.5 12
11.5 11
10.5 10
12.2 -19% 11.6 11.3 10.8 -13% 11.6
TEWL ***
*** p<0.0001 ** p<0.001
**
p<0.01 -28%
d28
postM placebo
d0
d28
postM 5% NA
d0
d28
T
G
Billion Arbitrary Unit (AU)
Corneometer units
Million Arbitrary Unit (AU)
TEWL
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114
